{"created":"2023-08-02T03:58:13.462589+00:00","id":7385,"links":{},"metadata":{"_buckets":{"deposit":"89ce2577-737b-43f6-a8ad-495ae555417f"},"_deposit":{"created_by":10,"id":"7385","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7385"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007385","sets":["1:9","2:12"]},"author_link":["27476","2308","27477","27478","27479","27480","27481","27482","27483","27484"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"445","bibliographicPageStart":"434","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"The Journal of Neuroscience"},{"bibliographic_title":"The Journal of Neuroscience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Neuroscience"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1523/JNEUROSCI.4374-07.2008","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Colak, Dilek, et al. \"Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.\" Journal of Neuroscience 28.2 (2008): 434-446."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jneurosci.org/content/28/2/434"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jneurosci.org/content/28/2/434","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2008 Society for Neuroscience"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10620404","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02706474","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research"},{"subitem_text_language":"en","subitem_text_value":"Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research"},{"subitem_text_language":"en","subitem_text_value":"Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich"},{"subitem_text_language":"en","subitem_text_value":"Institute for Pharmacology and Toxicology, University of Bonn"},{"subitem_text_language":"en","subitem_text_value":"Institute of Anatomy, University of Zurich"},{"subitem_text_language":"en","subitem_text_value":"Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health"},{"subitem_text_language":"en","subitem_text_value":"Developmental Biology, Hubrecht Institute"},{"subitem_text_language":"en","subitem_text_value":"Developmental Biology, Hubrecht Institute"},{"subitem_text_language":"en","subitem_text_value":"Institute of Anatomy, University of Zurich"},{"subitem_text_language":"en","subitem_text_value":"Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research / Physiological Genomics, University of Munich"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Development/Plasticity/Repair"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Colak, Dilek","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2308","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30285043","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30285043"},{"nameIdentifier":"100001237","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001237_ja.html"}]},{"creatorNames":[{"creatorName":"S., Brill Monika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Pfeifer, Alexander","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Falk, Sven","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Deng, Chuxia","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Monteiro, Rui","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mummery, Christine","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sommer, Lukas","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Götz, Magdalena","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27484","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"jn28(2)_434.pdf","filesize":[{"value":"674.6 kB"}],"format":"application/pdf","licensefree":"Copyright © 2008 Society for Neuroscience","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jn28(2)_434.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7385/files/jn28(2)_434.pdf"},"version_id":"444290b9-1bba-405e-8bfd-4aef632cc970"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"neural stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Olig2","subitem_subject_scheme":"Other"},{"subitem_subject":"Dlx2","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"oligodendrocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"neural stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Olig2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dlx2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oligodendrocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-12-24"},"publish_date":"2019-12-24","publish_status":"0","recid":"7385","relation_version_is_last":true,"title":["Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:48:46.125192+00:00"}