{"created":"2023-08-02T03:58:13.789789+00:00","id":7390,"links":{},"metadata":{"_buckets":{"deposit":"d7a648df-1468-4338-be4f-f40d0db0d3be"},"_deposit":{"created_by":10,"id":"7390","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7390"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007390","sets":["1:7","2:12"]},"author_link":["4889","4741","4880","27498","27499"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"50","bibliographicPageStart":"41","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"Vascular Pharmacology"},{"bibliographic_title":"Vascular Pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"High-dose imatinib reverses cardiopulmonary remodeling but adverse effects limit its clinical use. Efficacy of the multi-kinase inhibitor sunitinib remains questionable. We compared anti-remodeling effects of imatinib with sunitinib on monocrotaline-induced right ventricular (RV) hypertrophy and pulmonary arterial remodeling in rats, focusing on a lower dose. Fourteen days after monocrotaline injection, oral gavage of imatinib (5, 15, or 50mg/kg), sunitinib (0.3, 1, 3, or 10mg/kg), or water for 14days was started. RV hypertrophy and b-type natriuretic peptide mRNA levels were significantly and dose-dependently reduced, much greater in imatinib- than sunitinib-treated groups. Imatinib normalized muscularization of 20–50μm intra-acinar pulmonary arteries more significantly than sunitinib. At transcript levels, sunitinib significantly upregulated pulmonary nestin, and downregulated platelet-derived growth factor receptor beta (PDGFR-β), fibroblast growth factor receptor 1, vascular endothelial growth factor receptor-2 and vascular endothelial growth factor (VEGF)-A, but not Raf-1 proto-oncogene serine/threonine kinase mRNAs. Sunitinib also suppressed VEGF-A, but not phosphorylated extra-cellular-signal-related kinase (ERK)-1/2 protein expression. The sole PDGFR-β antagonism of imatinib resulted in significant Raf-1 mRNA and phosphorylated ERK-1/2 protein downregulation, suggesting that the equivocal reversal effect of sunitinib may be due to its VEGF signaling inhibition in the lung. Imatinib's greater dose-dependent reversal on cardiopulmonary remodeling may make a low dose suitable for PAH treatment.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.vph.2017.10.006","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Leong, Zi Ping. Okida, Ayumi. Higuchi, Masahi. et al. Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats. Vascular Pharmacology. 100. 41-50. 2018. doi:10.1016/j.vph.201"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/science/article/pii/S1537189117302148"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S1537189117302148","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15371891","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"The United Graduate School of Veterinary Science, Yamaguchi University / Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 雅司"},{"creatorName":"ヒグチ, マサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Higuchi, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4889","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70614791","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70614791"},{"nameIdentifier":"100001620","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001620_ja.html"}]},{"creatorNames":[{"creatorName":"山野, 好章"},{"creatorName":"ヤマノ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamano, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4741","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00182593","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00182593"},{"nameIdentifier":"100000678","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000678_ja.html"}]},{"creatorNames":[{"creatorName":"日笠, 喜朗"},{"creatorName":"ヒカサ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hikasa, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4880","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30165071","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30165071"},{"nameIdentifier":"100000653","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000653_ja.html"}]},{"creatorNames":[{"creatorName":"Leong, Zi Ping","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okida, Ayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27499","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"vp100_41.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensefree":"(C) 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"vp100_41.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7390/files/vp100_41.pdf"},"version_id":"566ac9da-e0d0-4368-b8a3-1cdf857cf63d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cardiopulmonary remodeling","subitem_subject_scheme":"Other"},{"subitem_subject":"Imatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"Sunitinib","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonary arterial hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiopulmonary remodeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Imatinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sunitinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonary arterial hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-09-08"},"publish_date":"2022-09-08","publish_status":"0","recid":"7390","relation_version_is_last":true,"title":["Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-11-22T01:51:36.392525+00:00"}