{"created":"2023-08-02T03:58:15.809153+00:00","id":7422,"links":{},"metadata":{"_buckets":{"deposit":"5cea4286-1cd6-43fa-94e9-1f862f766b4e"},"_deposit":{"created_by":10,"id":"7422","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7422"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007422","sets":["1:9","2:12"]},"author_link":["27555","1772","27556"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"23","bibliographicPageStart":"14","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"細胞工学","bibliographic_titleLang":"ja"},{"bibliographic_title":"細胞工学","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　ヒトゲノムの解読により, タンパクをコードするmRNAは全RNAのわずか1.5％に過ぎず, 残りの98％はタンパクをコードしていない非コードRNA(non-coding RNA: ncRNA)で占めていることが明らかとなった. それに加え, 近年, ENCODEプロジェクトにおいて, 長鎖非コードRNA(long non-coding RNA: lncRNA)は, ヒトの〜9000ものゲノム領域から転写されていた1). これまでlncRNAには, がん抑制遺伝子Ink4遺伝子座の発現制御に関わるANRIL, ゲノムインプリンティングに関わるKCNQ1OT1/LIT1, Air, HOX遺伝子の転写抑制に関わるHOTAIRなどが知られている. 最近では, 代謝の再プログラミング化に関与するlncRNAとしてlincRNA-p21が見出された. このように, lncRNAもまた機能性RNAとして様々な生体制御機構に重要な役割を担っている.　本稿では, lncRNAの中でもクロマチン上に集積(コーティング)することで染色体全体あるいは, 局所的にヘテロクロマチン化を誘導するユニークな遺伝子発現制御に関わるXistおよびKCNQ1OT1/LIT1に着目し, 最新の知見から遺伝子発現制御や疾患との関わりについて考察する.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"学研メディカル秀潤社"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"細胞工学. 2015, 34(1), 14-23"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00069897","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02873796","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"チョウサ　ノンコーディング　RNA　ニヨル　センショクタイ　ドメイン　レベル　ノ　イデンシ　ハツゲン　セイギョ"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"鳥取大学大学院医学系研究科機能再生医科学専攻遺伝機能工学部門/鳥取大学染色体工学研究センター"},{"subitem_text_value":"鳥取大学大学院医学系研究科機能再生医科学専攻遺伝機能工学部門/鳥取大学染色体工学研究センター"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"砂村, 直洋"},{"creatorName":"スナムラ, ナオヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久郷, 裕之"},{"creatorName":"クゴウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kugoh, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sunamura, Naohiro","creatorNameLang":"en"},{"creatorName":"スナムラ, ナオヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-01-22"}],"displaytype":"detail","filename":"ct34(1)_14.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ct34(1)_14.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7422/files/ct34(1)_14.pdf"},"version_id":"65a1baaa-b382-4d39-a465-4881ec3a00c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"長鎖非コードRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"XIST","subitem_subject_scheme":"Other"},{"subitem_subject":"KCNQ1OT1/LIT1","subitem_subject_scheme":"Other"},{"subitem_subject":"X染色体不活性化","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現制御","subitem_subject_scheme":"Other"},{"subitem_subject":"長鎖非コードRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"XIST","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"KCNQ1OT1/LIT1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"X染色体不活性化","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現制御","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"長鎖ノンコーディングRNA による染色体ドメインレベルの遺伝子発現制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"長鎖ノンコーディングRNA による染色体ドメインレベルの遺伝子発現制御","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"7422","relation_version_is_last":true,"title":["長鎖ノンコーディングRNA による染色体ドメインレベルの遺伝子発現制御"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:27:12.894281+00:00"}