| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-21 |
| タイトル |
|
|
タイトル |
A Strategic Translational Research System for Drug Discovery in Tottori University |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
drug discovery |
| キーワード |
|
|
言語 |
en |
|
主題 |
open innovation |
| キーワード |
|
|
言語 |
en |
|
主題 |
translational research |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
遠藤,佑輔
Yoshida,Tsutomu
Washijima,Ichiro
植木,賢
Kikuchi,Noriyoshi
武中,篤
河田,康志
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Organization for Research Institute and Promotion, Tottori University |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The probability of successful drug discovery is declining, and research and development costs are increasing. To solve these problems, pharmaceutical companies tend to in-license seeds from venture companies and academia. Therefore, academia’s role in drug discovery is extremely important. Tottori University started a “Next-Generation Research Support Project (Strategic Research Support Project)” in 2020, developing a translational research system to promote drug discovery. In this project, we established a research and development infrastructure, such as seed registration, construction of drug research and development support, and research fund allocation. The registered seed were converted into project, and the project implemented this research and development system, and evaluated and verified its results. Twenty-two seeds were converted into projects and portfolios were constructed. Research funds were allocated to eight prioritized projects. Each project raised the research and development stages. From the overall portfolio, one project with the Japan Agency for Medical Research and Development (AMED) Drug Discovery Booster Project, and three projects with Seeds A of the AMED Translational Research Strategic Promotion Program were adopted. Additionally, a new low-molecular weight chaperone drug against GM1-gangliosidosis was out-licensed to an overseas pharmaceutical company. The strength of this system was the strategic allocation of research funds and the accompanying support that leveraged internal and external resources with the PM and researchers at its core. This system achieved certain results in promoting drug discovery; however, resource optimization of specialized personnel needs to be strengthened in the future. In this report, we summarized the efforts of translational research in Japan and around the world. In addition, the translational research efforts of Japanese academia and Tottori University were compared and the current status was summarized. |
|
言語 |
en |
| 書誌情報 |
en : Yonago Acta Medica
巻 66,
号 4,
p. 394-403,
ページ数 10,
発行日 2023-11-28
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| 出版者 |
|
|
出版者 |
Tottori University Medical Press |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
(C)2023 Tottori University Medical Press |
| 情報源 |
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|
関連名称 |
Yonago Acta Medica. 2023, 66(4), 394-403. |
| 関連サイト |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-4/66-4contents.html |
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|
関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam66-4/66-4contents.html |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.33160/yam.2023.11.001 |
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|
関連名称 |
https://doi.org/10.33160/yam.2023.11.001 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
yam66(4)_394.pdf
