| アイテムタイプ |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2024-12-23 |
| タイトル |
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|
タイトル |
Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA) |
|
言語 |
en |
| 作成者 |
Nemoto,Hideyuki
Otake,Marina
Matsumoto,Takahiro
Izutsu,Runa
Jehung,Jumond P
Goto,Keisuke
WEKO
499
| ja |
Goto,Keisuke（Personal）
kakenhi 鳥取大学
15101
|
| en |
Goto,Keisuke（Personal）
Tottori University
|
| ja-Kana |
ゴトウ,ケイスケ（Personal）
|
Search repository
尾崎,充彦
Mayama,Masafumi
Shikanai,Masataka
Kobayashi,Hiroshi
Watanabe,Tetsushi
岡田,太
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| 主題 |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Inflammation-related carcinogenesis |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemoprevention |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tumor progression |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Metastasis |
| 主題 |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Somatic mutation |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) has shown chemopreventive effectiveness against inflammation-related carcinogenesis, by inhibiting inflammation. We found that Aspergillus oryzae is the main component of the anti-inflammatory effect of FBRA and that the intestinal flora is involved. Mice fed FBRA were found to have a lower tumor-forming rate than mice fed the basic diet. Tumor cell lines obtained from basic diet-fed mice metastasized to distant organs. By contrast, those from FBRA-fed mice acquired reduced metastatic capacity. Micronucleus testing detected somatic mutations in tumor cell lines directly established from primary tumors; these decreased in a dose-dependent manner in FBRA-fed mice. To determine whether FBRA ingestion induced systemic anti-mutagenicity, micronucleus testing was performed using reticulocytes in mice injected with typical mutagens. Mutations induced by these mutagens were suppressed in FBRA-fed mice. These results indicate that anti-inflammation and anti-mutagenicity induced by FBRA intake suppressed the inflammation-related carcinogenic process. |
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言語 |
en |
| 出版者 |
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出版者 |
Elsevier BV |
|
言語 |
en |
| 日付 |
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日付 |
2021-12-22 |
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日付タイプ |
Issued |
| 言語 |
|
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.jff.2021.104907 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
22149414 |
| 収録物名 |
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収録物名 |
Journal of Functional Foods |
|
言語 |
en |
| 巻 |
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|
巻 |
88 |
| 開始ページ |
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開始ページ |
104907 |
| 書誌情報 |
en : Journal of Functional Foods
巻 88,
p. 104907,
発行日 2021-12-22
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| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
(C) 2021 The Author(s). Published by Elsevier Ltd. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). |
|
言語 |
en |
jff88_104907.pdf (1.4 MB)
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