| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-10-01 |
| タイトル |
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|
タイトル |
A Case of High-Dose Intravenous MgSO4 and Hemoperfusion for Aconite Poisoning with Chronic Kidney Disease |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aconitum |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
arrhythmias |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chronic kidney disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hemoperfusion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
magnesium sulfate |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Oshima,Yoshiaki
田中,明
Fukuki,Masaharu
大槻,明広
久留,一郎
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| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Aconite contains four highly toxic diester-diterpene alkaloids, including aconitine, mesaconitine, hypaconitine, and jesaconitine, in all plant parts. Aconite has been used as for suicide, murder, and as an arrow poison since ancient Greek and Roman times. Ventricular tachyarrhythmias are the most common cause of death in aconite poisoning, and antiarrhythmic drugs and cardioversion are ineffective. A 61-year-old woman ingested the crushed raw roots of a single aconite plant. An ambulance brought her to the Tottori University Hospital 30 min after ingestion. She had a history of chronic stage 5 kidney disease but was not on dialysis. Her heart rate (HR) was 120 bpm upon arrival. The patient developed sustained supraventricular tachycardia (SVT) at an HR of 165 bpm with frequent premature ventricular contractions (PVCs) 15 min after arrival. She then developed sustained monomorphic ventricular tachycardia (VT) at an HR of 200 bpm 20 min after arrival, which progressed to pulseless polymorphic VT. Cardioversion was unsuccessful. External cardiac massage restored spontaneous circulation; however, her underlying rhythm remained sustained SVT with frequent PVCs. These arrhythmias repeatedly led to circulatory arrest. She was administered six intravenous boluses of 2 g of MgSO4 in the emergency department, which prevented her from going into sustained pulseless VT. Hemoperfusion (HP) with activated charcoal was performed 1.5 h after arrival. The aconitine, mesaconitine, and hypaconitine plasma concentrations were high at 8.9, 23.5, and 5.5 ng/mL, respectively, before the start of HP but decreased to 1.7, 4.0, and 2.7 ng/mL, respectively, after 7 h of HP. She returned to sinus rhythm on the second day of hospitalization; however, the patient required maintenance hemodialysis. We concluded that high-dose IV MgSO4 is an effective treatment for fatal tachyarrhythmias due to aconite poisoning, and that in cases of renal failure, HP may be required to remove aconite toxins from the body. |
|
言語 |
en |
| 書誌情報 |
en : Yonago Acta Medica
巻 67,
号 3,
p. 270-279,
ページ数 10,
発行日 2024-08-26
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| 出版者 |
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|
出版者 |
Tottori University Medical Press |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
05135710 |
| ISSN |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
(C)2024 Tottori University Medical Press |
| 情報源 |
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|
関連名称 |
Yonago Acta Medica. 2024, 67(3), 270-279. |
| 関連サイト |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam67-3/67-3contents.html |
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関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam67-3/67-3contents.html |
| 関連サイト |
|
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.33160/yam.2024.08.012 |
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|
関連名称 |
https://doi.org/10.33160/yam.2024.08.012 |
| 著者版フラグ |
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出版タイプ |
VoR |
yam67(3)_270.pdf (1.7 MB)
