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A randomized clinical trial on effects of alfaxalone combined with medetomidine and midazolam in preventing stress-related neurohormonal and metabolic responses of isoflurane-anesthetized cats undergoing surgery
https://repository.lib.tottori-u.ac.jp/records/2001695
https://repository.lib.tottori-u.ac.jp/records/2001695bd506919-a4a7-4254-ae43-0d27da87d653
| 名前 / ファイル | ライセンス | アクション |
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ajvr83(11)_1.pdf (518.4 KB)
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||||||||
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| 公開日 | 2025-02-12 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | A randomized clinical trial on effects of alfaxalone combined with medetomidine and midazolam in preventing stress-related neurohormonal and metabolic responses of isoflurane-anesthetized cats undergoing surgery | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Kamohara,Hirokazu
× Kamohara,Hirokazu
× Kamohara,Toshiko
× 日笠,喜朗
WEKO
4880
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| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | OBJECTIVE: To evaluate the effects of IM and IV administration of alfaxalone alone and in combination with medetomidine, midazolam, or both on key stress-related neurohormonal and metabolic changes in isoflurane-anesthetized cats undergoing ovariohysterectomy or castration. ANIMALS: 72 client-owned mixed-breed cats undergoing ovariohysterectomy or castration between October 4, 2018, and January 10, 2020. PROCEDURES: For each type of surgery, cats were assigned to 1 of 6 premedication protocols groups, with 6 cats/group: physiologic saline (0.9% NaCl) solution (0.5 mL, IM) and alfaxalone (5 mg/kg, IV); physiologic saline solution (0.5 mL, IM) and alfaxalone (5 mg/kg, IM); medetomidine (50 μg/kg, IM) and alfaxalone (5 mg/kg, IV); medetomidine (50 μg/kg, IM) and alfaxalone (5 mg/kg, IM); midazolam (0.5 mg/kg, IM), medetomidine (50 μg/kg, IM), and alfaxalone (5 mg/kg, IV); or midazolam (0.5 mg/kg, IM), medetomidine (50 μg/kg, IM), and alfaxalone (5 mg/kg, IM). Venous blood was taken before pretreatment, pre- and postoperatively during anesthesia with isoflurane and oxygen, and during early and complete recovery. RESULTS: Compared with baseline concentrations, plasma adrenaline and noradrenaline concentrations decreased during anesthesia in cats premedicated with alfaxalone alone and in combination with medetomidine. The combination of medetomidine, midazolam, and alfaxalone prevented an excessive increase in catecholamines during anesthesia and surgery in cats. Postoperative plasma cortisol concentration after ovariohysterectomy was lower for cats premedicated with the combination of medetomidine and alfaxalone or the combination of medetomidine, midazolam, and alfaxalone, compared with cats premedicated with alfaxalone alone. Cats treated with combinations that included medetomidine and midazolam had hyperglycemia during anesthesia. Cats treated with medetomidine or medetomidine and midazolam in combination with alfaxalone, compared with alfaxalone alone, had lower concentrations of nonesterified fatty acids during anesthesia. Behavioral recovery scores were lower (better) for cats that received medetomidine in addition to alfaxalone, compared with alfaxalone alone. CLINICAL RELEVANCE: Results indicated that pretreatments with medetomidine and alfaxalone or with medetomidine, midazolam, and alfaxalone were useful for preventing stress-related hormonal and metabolic responses, other than hyperglycemia, during isoflurane anesthesia and surgery in cats. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | American Veterinary Medical Association (AVMA) | |||||||||||||||
| 言語 | en | |||||||||||||||
| 日付 | ||||||||||||||||
| 日付 | 2022-09-19 | |||||||||||||||
| 日付タイプ | Issued | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.2460/ajvr.22.03.0041 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 00029645 | |||||||||||||||
| 収録物名 | ||||||||||||||||
| 収録物名 | American journal of veterinary research | |||||||||||||||
| 言語 | en | |||||||||||||||
| 巻 | ||||||||||||||||
| 巻 | 83 | |||||||||||||||
| 号 | ||||||||||||||||
| 号 | 11 | |||||||||||||||
| 開始ページ | ||||||||||||||||
| 開始ページ | 1 | |||||||||||||||
| 書誌情報 |
en : American journal of veterinary research 巻 83, 号 11, 発行日 2022-09-19 |
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | (C) 2022 THE AUTHORS. Published by the American Veterinary Medical Association. This work is licensed under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/ | |||||||||||||||
