| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-21 |
| タイトル |
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|
タイトル |
Medium-Chain Triglyceride Administration Induces Antidepressant Effects in Animal Models by Increasing Beta-Hydroxybutyrate Levels |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
beta-hydroxybutyrate |
| キーワード |
|
|
言語 |
en |
|
主題 |
depression |
| キーワード |
|
|
言語 |
en |
|
主題 |
triglyceride |
| 資源タイプ |
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|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
| 著者 |
三浦,明彦
山梨,豪彦
梶谷,直史
Fukuda,Saki
Tsunetomi,Kyohei
松尾,諒一
西口,毅
朴,盛弘
Nakada,Yumeto
白山,幸彦
Watanabe,Ken
兼子,幸一
岩田,正明
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| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
Background: Inflammation is believed to contribute to the pathophysiology of depression, with increased levels of inflammatory cytokines, such as interleukin-1β (IL1β), observed in patients. Depression is also common in individuals with chronic inflammatory diseases. IL-1β disrupts synaptic transmission and reduces neurogenesis in the hippocampus, playing a crucial role in depression development. Our prior research found that stress activates microglia in the brain to produce IL-1β via the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. Additionally, β-hydroxybutyrate (BHB), an endogenous ketone body, alleviates stress-induced depression by inhibiting NLRP3 activation and IL-1β production. However, BHB’s poor bioavailability limits its effectiveness. Medium-chain triglycerides (MCTs) can increase blood BHB levels, making them a potential treatment for stress-induced depression. Methods: We tested MCT in two animal models: social defeat (SD) in mice and chronic unpredictable stress (CUS) in rats. MCT was orally administered to both groups to assess blood BHB levels. Behavioral tests, including the forced swim test (FST), were performed, and brain tissue was analyzed for IL-1β levels and spine density. Results: MCT administration increased blood BHB levels 7–11 times within 1 hour. In the SD model, MCT significantly reduced immobility time in the FST, suggesting antidepressant effects. While the CUS model showed no significant change, a trend toward reduced immobility time was observed. MCT treatment also reduced stress-induced IL-1β levels in the rat hippocampus, although spine density remained unchanged. Conclusion: MCT appears to alleviate stress-induced depression-like behaviors, likely through the suppression of IL-1β in the hippocampus. Owing to its ease of oral administration, MCT may offer a practical treatment for stress-related depression. |
|
言語 |
en |
| 書誌情報 |
en : Yonago Acta Medica
巻 68,
号 1,
p. 58-67,
ページ数 10,
発行日 2025-02-21
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| 出版者 |
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|
出版者 |
Tottori University Medical Press |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
05135710 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
(C) 2025 Tottori University Medical Press |
| 情報源 |
|
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|
言語 |
en |
|
|
関連名称 |
Akihiko Miura, Takehiko Yamanashi, Naofumi Kajitani, Saki Fukuda, Kyohei Tsunetomi, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Shenghong Pu, Yumeto Nakada, Yukihiko Shirayama, Ken Watanabe, Koichi Kaneko, Masaaki Iwata. Medium-Chain Triglyceride Administration Induces Antidepressant Effects in Animal Models by Increasing Beta-Hydroxybutyrate Levels. Yonago Acta Medica, 2025, 68(1), 58-67, doi: https://doi.org/10.33160/yam.2025.02.007 |
| 関連サイト |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.33160/yam.2025.02.007 |
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関連名称 |
https://doi.org/10.33160/yam.2025.02.007 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html |
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関連名称 |
https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html |
| 著者版フラグ |
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|
出版タイプ |
VoR |
yam68(1)_58.pdf (2 MB)
