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Clinical Significance of Subcellular Localization of Maspin in Breast Carcinoma: An Immunohistochemical Study Using Two Different Antibodies
https://repository.lib.tottori-u.ac.jp/records/4605
https://repository.lib.tottori-u.ac.jp/records/4605863bafa8-323f-4d18-aa32-23dcc833abc9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam66(1)_19.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-28 | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of Subcellular Localization of Maspin in Breast Carcinoma: An Immunohistochemical Study Using Two Different Antibodies | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | breast carcinoma | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | maspin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | breast carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | maspin | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
若原, 誠
× 若原, 誠× Hosoya, Keiko× 梅北, 善久× Hosoya, Keiko× Ishii, Hiroshi |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of General Thoracic Surgery and Breast and Endocrine Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of General Thoracic Surgery and Breast and Endocrine Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University / Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Maspin is known to be a tumor suppressor protein: however, its prognostic value in patients with breast cancer remains controversial. The key influential factors contributing to this complexity may be the differences in antibodies used, as well as the positive criteria and sample size. To date, no study has investigated the prognostic significance of maspin expression by using two different antibodies in the same cohort. We aimed to clarify whether differences in antibodies could influence on the prognostic value of maspin in breast cancer patients. Methods: Immunohistochemical analyses using an anti-maspin antibody (clone G167-70) were performed on 164 resected specimens of invasive carcinoma of no special type (NOS). The correlation with clinicopathological factors was compared to previous results using clone EAW24, with longer follow-up duration. Results: The subcellular localization of maspin expression was as follows: cytoplasmic-only staining, 3 cases (1.8%), pancellular staining, 43 cases (26.2%); and no staining, 118 cases (72.0%). No nuclear-only staining was observed. There was no significant correlation between clinicopathological characteristics and the pancellualr expression of maspin. The pancellular expression group showed a significantly longer disease-free survival (DFS) than the other groups (P = 0.046). When clone EAW24 was used, the cytoplasmic-only staining group showed significantly shorter DFS than the pancellular staining group (P = 0.003). Conclusion: Clone EAW24 may be superior to clone G167-70 in selecting breast carcinoma with an aggressive phenotype, while clone G167-70 may be superior to clone EAW24 in selecting non-aggressive breast carcinoma. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 66, 号 1, p. 19-23, 発行日 2023-02-20 |
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| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2023.02.003 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2023 Tottori University Medical Press. | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2023, 66(1), 19-23. doi:10.33160/yam.2023.02.003 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連名称 | https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.33160/yam.2023.02.003 | |||||
| 関連名称 | https://doi.org/10.33160/yam.2023.02.003 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 13468049 | |||||
