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Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients
https://repository.lib.tottori-u.ac.jp/records/4720
https://repository.lib.tottori-u.ac.jp/records/4720725cbe3c-f8a3-4419-9d94-fa5255d1a62d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam63(1)_70.pdf (946.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-28 | |||||
| タイトル | ||||||
| タイトル | Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | CRP | |||||
| キーワード | ||||||
| 主題 | pancreatic cancer | |||||
| キーワード | ||||||
| 主題 | platelet | |||||
| キーワード | ||||||
| 主題 | prognosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | CRP | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | pancreatic cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | platelet | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Morimoto, Masaki
× Morimoto, Masaki× Honjo, Soichiro× Sakamoto, Teruhisa× Yagyu, Takuki× Uchinaka, Ei× Hanaki, Takehiko× Watanabe, Joji× Matsunaga, Tomoyuki× Yamamoto, Manabu× Fukumoto, Yoji× Tokuyasu, Naruo× Fujiwara, Yoshiyuki |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: C-reactive protein (CRP) levels reflect ongoing inflammation and/or tissue damage, and studies suggest that platelets play a role in tumor invasion and metastasis. P-CRP is defined as the multiplied product of serum CRP and platelet levels. Here the prognostic value of pre- and post-operative P-CRP levels in pancreatic cancer (PC) patients was assessed. Methods: This retrospective study used data from 107 consecutive PC patients who had undergone either pancreaticoduodenectomy or distal pancreatectomy. Clinicopathological parameters and pre/post-operative laboratory data derived from patient records were used for analyses. P-CRP was defined as the product of peripheral thrombocyte count (/uL) × serum CRP level (mg/dL) divided by 104; the optimal P-CRP cut-off value was defined using receiver operating characteristic curves. Results: PC patients were classified as either P-CRPLow (< 1.782; n = 49) or P-CRPHigh (≥ 1.782; n = 58), based on the cut-off value of 1.782. Univariate analysis revealed that performance status, clinical stage, pathological T and N stages, P-CRP, and carbohydrate antigen 19-9 (CA19-9) significantly affected overall survival (OS). Multivariate analysis revealed that independent risk factors for OS were pathological N stage, P-CRP, and CA19-9. Additionally, 103 PC patients for whom postoperative data were available were classified into four groups (P-CRPLow-Down, P-CRPLow-Up, P-CRPHigh-Down and P-CRPHigh-Up), based on preoperative P-CRP and postoperative trend of P-CRP, and we found that prognosis, in terms of OS, was significantly different among these groups (P = 0.012). Conclusion: Pre- and post-operative P-CRP values are a potential predictor of prognosis in PC patients. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 63, 号 1, p. 70-78, 発行日 2020-02-20 |
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| 雑誌内区分 | ||||||
| 値 | Original Article | |||||
| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2020.02.011 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Takehiko Hanaki, Joji Watanabe, Tomoyuki Matsunaga, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Yoshiyuki Fujiwara, Prognostic Impact of Pre- and Post-operative P-CRP Level | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/ | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
