| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-02-28 |
| タイトル |
|
|
タイトル |
Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CRP |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pancreatic cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
platelet |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
prognosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CRP |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pancreatic cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
platelet |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Morimoto, Masaki
Honjo, Soichiro
Sakamoto, Teruhisa
Yagyu, Takuki
Uchinaka, Ei
Hanaki, Takehiko
Watanabe, Joji
Matsunaga, Tomoyuki
Yamamoto, Manabu
Fukumoto, Yoji
Tokuyasu, Naruo
Fujiwara, Yoshiyuki
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Background: C-reactive protein (CRP) levels reflect ongoing inflammation and/or tissue damage, and studies suggest that platelets play a role in tumor invasion and metastasis. P-CRP is defined as the multiplied product of serum CRP and platelet levels. Here the prognostic value of pre- and post-operative P-CRP levels in pancreatic cancer (PC) patients was assessed. Methods: This retrospective study used data from 107 consecutive PC patients who had undergone either pancreaticoduodenectomy or distal pancreatectomy. Clinicopathological parameters and pre/post-operative laboratory data derived from patient records were used for analyses. P-CRP was defined as the product of peripheral thrombocyte count (/uL) × serum CRP level (mg/dL) divided by 104; the optimal P-CRP cut-off value was defined using receiver operating characteristic curves. Results: PC patients were classified as either P-CRPLow (< 1.782; n = 49) or P-CRPHigh (≥ 1.782; n = 58), based on the cut-off value of 1.782. Univariate analysis revealed that performance status, clinical stage, pathological T and N stages, P-CRP, and carbohydrate antigen 19-9 (CA19-9) significantly affected overall survival (OS). Multivariate analysis revealed that independent risk factors for OS were pathological N stage, P-CRP, and CA19-9. Additionally, 103 PC patients for whom postoperative data were available were classified into four groups (P-CRPLow-Down, P-CRPLow-Up, P-CRPHigh-Down and P-CRPHigh-Up), based on preoperative P-CRP and postoperative trend of P-CRP, and we found that prognosis, in terms of OS, was significantly different among these groups (P = 0.012). Conclusion: Pre- and post-operative P-CRP values are a potential predictor of prognosis in PC patients. |
| 書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 63,
号 1,
p. 70-78,
発行日 2020-02-20
|
| 雑誌内区分 |
|
|
値 |
Original Article |
| 出版者 |
|
|
出版者 |
Tottori University Medical Press |
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
05135710 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.33160/yam.2020.02.011 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
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|
関連名称 |
Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Takehiko Hanaki, Joji Watanabe, Tomoyuki Matsunaga, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Yoshiyuki Fujiwara, Prognostic Impact of Pre- and Post-operative P-CRP Level |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/ |
|
|
関連名称 |
https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/ |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html |
|
|
関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
| EISSN |
|
|
値 |
1346-8049 |
yam63(1)_70.pdf (946.7 kB)
