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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 63
  4. 1

Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients

https://repository.lib.tottori-u.ac.jp/records/4720
https://repository.lib.tottori-u.ac.jp/records/4720
725cbe3c-f8a3-4419-9d94-fa5255d1a62d
名前 / ファイル ライセンス アクション
yam63(1)_70.pdf yam63(1)_70.pdf (946.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-02-28
タイトル
タイトル Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients
言語 en
言語
言語 eng
キーワード
主題 CRP
キーワード
主題 pancreatic cancer
キーワード
主題 platelet
キーワード
主題 prognosis
キーワード
言語 en
主題 CRP
キーワード
言語 en
主題 pancreatic cancer
キーワード
言語 en
主題 platelet
キーワード
言語 en
主題 prognosis
資源タイプ
資源タイプ journal article
著者 Morimoto, Masaki

× Morimoto, Masaki

WEKO 2271
e-Rad 40808953
研究者総覧鳥取大学 100001446

en Morimoto, Masaki

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Honjo, Soichiro

× Honjo, Soichiro

WEKO 780
研究者総覧鳥取大学 100000247

en Honjo, Soichiro

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Sakamoto, Teruhisa

× Sakamoto, Teruhisa

WEKO 3118
研究者総覧鳥取大学 100000935

en Sakamoto, Teruhisa

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Yagyu, Takuki

× Yagyu, Takuki

WEKO 16860

en Yagyu, Takuki

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Uchinaka, Ei

× Uchinaka, Ei

WEKO 16861

en Uchinaka, Ei

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Hanaki, Takehiko

× Hanaki, Takehiko

WEKO 16862

en Hanaki, Takehiko

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Watanabe, Joji

× Watanabe, Joji

WEKO 4168
研究者総覧鳥取大学 100000915

en Watanabe, Joji

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Matsunaga, Tomoyuki

× Matsunaga, Tomoyuki

WEKO 2048
研究者総覧鳥取大学 100001316

en Matsunaga, Tomoyuki

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Yamamoto, Manabu

× Yamamoto, Manabu

WEKO 4296
研究者総覧鳥取大学 100001149

en Yamamoto, Manabu

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Fukumoto, Yoji

× Fukumoto, Yoji

WEKO 426
e-Rad 40623947
研究者総覧鳥取大学 100000414

en Fukumoto, Yoji

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Tokuyasu, Naruo

× Tokuyasu, Naruo

WEKO 3905
研究者総覧鳥取大学 100000393

en Tokuyasu, Naruo

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Fujiwara, Yoshiyuki

× Fujiwara, Yoshiyuki

WEKO 377
e-Rad 40314330
研究者総覧鳥取大学 100001755

en Fujiwara, Yoshiyuki

Search repository
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Background: C-reactive protein (CRP) levels reflect ongoing inflammation and/or tissue damage, and studies suggest that platelets play a role in tumor invasion and metastasis. P-CRP is defined as the multiplied product of serum CRP and platelet levels. Here the prognostic value of pre- and post-operative P-CRP levels in pancreatic cancer (PC) patients was assessed. Methods: This retrospective study used data from 107 consecutive PC patients who had undergone either pancreaticoduodenectomy or distal pancreatectomy. Clinicopathological parameters and pre/post-operative laboratory data derived from patient records were used for analyses. P-CRP was defined as the product of peripheral thrombocyte count (/uL) × serum CRP level (mg/dL) divided by 104; the optimal P-CRP cut-off value was defined using receiver operating characteristic curves. Results: PC patients were classified as either P-CRPLow (< 1.782; n = 49) or P-CRPHigh (≥ 1.782; n = 58), based on the cut-off value of 1.782. Univariate analysis revealed that performance status, clinical stage, pathological T and N stages, P-CRP, and carbohydrate antigen 19-9 (CA19-9) significantly affected overall survival (OS). Multivariate analysis revealed that independent risk factors for OS were pathological N stage, P-CRP, and CA19-9. Additionally, 103 PC patients for whom postoperative data were available were classified into four groups (P-CRPLow-Down, P-CRPLow-Up, P-CRPHigh-Down and P-CRPHigh-Up), based on preoperative P-CRP and postoperative trend of P-CRP, and we found that prognosis, in terms of OS, was significantly different among these groups (P = 0.012). Conclusion: Pre- and post-operative P-CRP values are a potential predictor of prognosis in PC patients.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 63, 号 1, p. 70-78, 発行日 2020-02-20
雑誌内区分
値 Original Article
出版者
出版者 Tottori University Medical Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2020.02.011
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Takehiko Hanaki, Joji Watanabe, Tomoyuki Matsunaga, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Yoshiyuki Fujiwara, Prognostic Impact of Pre- and Post-operative P-CRP Level
関連サイト
識別子タイプ URI
関連識別子 https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/
関連名称 https://www.jstage.jst.go.jp/article/yam/63/1/63_2020.02.011/_article/
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam63-1/63-1contents.html
著者版フラグ
出版タイプ VoR
EISSN
値 1346-8049
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