| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-10-26 |
| タイトル |
|
|
タイトル |
The effect of Hangeshashinto on Oral Mucositis Caused by Induction Chemotherapy in Patients with Head and Neck Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
chemotherapy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gargling |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hangeshashinto |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
head and neck cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
oral mucositis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chemotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gargling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hangeshashinto |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
head and neck cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral mucositis |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Taira, Kenkichiro
Fujiwara, Kazunori
Fukuhara, Takahiro
Koyama, Satoshi
Takeuchi, Hiromi
|
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
| 著者所属（英） |
|
|
言語 |
en |
|
値 |
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
[Background] Oral mucositis (OM) is a side effect of chemotherapy in head and neck cancer. Severe OM often has a large impact on quality of life. Therefore, the treatment of OM during chemotherapy is very important. It was recently reported that Hangeshashinto (TJ-14), a Japanese traditional medicine (Kampo), is effective for OM caused by fluorinated pyrimidinebased agents used in colon cancer. We investigated the efficacy of TJ-14 for OM. [Methods] We enrolled patients with head and neck cancer who were treated with induction chemotherapy between September 2014 and March 2016. In this double-blind trial, patients were randomly assigned to the TJ-14 group or placebo group. Patients were instructed to dissolve 2.5 g of TJ-14 or placebo in 100 ml of drinking water, rinse their mouths with the solution for 30 s and then spit it out. They were not allowed to eat anything for 30 minutes before or after using the mouthwash. [Results] The incidence of ≥ grade 2 OM was 37.5% (three patients) in the TJ-14 group and 50.0% (four patients) in the placebo group, with no significant difference between the two groups. The mean day of onset was 9.7 in the TJ-14 group and 6.7 in the placebo group. The mean duration of ≥ grade 2 OM was 1.3 days in the TJ-14 group and 3.7 days in the placebo group. Thus TJ-14 significantly reduced the duration of ≥ grade 2 OM. [Conclusion] Treatment of OM with TJ-14 was associated with a statistically significant reduction in the duration of ≥ grade 2 OM compared to placebo. Gargling with TJ-14 is a safe and effective method of administering the drug to patients with head and neck cancer. |
| 書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 63,
号 3,
p. 183-187,
発行日 2020-08-20
|
| 雑誌内区分 |
|
|
値 |
Original Article |
| 出版者 |
|
|
出版者 |
Tottori University Medical Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
05135710 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.33160/yam.2020.08.007 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
|
|
関連名称 |
Taira Kenkichiro, Fujiwara Kazunori, Fukuhara Takahiro et al. The effect of Hangeshashinto on Oral Mucositis Caused by Induction Chemotherapy in Patients with Head and Neck Cancer. Yonago Acta Medica. 2020, 63(3). 183-187. doi: 10.33160/yam.2020.08.007. |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.007/_article/ |
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|
関連名称 |
https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.007/_article/ |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html |
|
|
関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
| EISSN |
|
|
値 |
1346-8049 |
yam63(3)_183.pdf (519.7 kB)
