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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 62
  4. 1

A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity

https://repository.lib.tottori-u.ac.jp/records/4764
https://repository.lib.tottori-u.ac.jp/records/4764
c4eb43e9-0abd-471d-9bdd-c1b42b966d41
名前 / ファイル ライセンス アクション
yam62(1)_14.pdf yam62(1)_14.pdf (801.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-17
タイトル
タイトル A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity
言語 en
言語
言語 eng
キーワード
主題 dietary fiber
キーワード
主題 fucoidan
キーワード
主題 glucagon-like peptide1
キーワード
主題 taste sensitivity
キーワード
主題 type 2 diabetes mellitus
キーワード
言語 en
主題 dietary fiber
キーワード
言語 en
主題 fucoidan
キーワード
言語 en
主題 glucagon-like peptide1
キーワード
言語 en
主題 taste sensitivity
キーワード
言語 en
主題 type 2 diabetes mellitus
資源タイプ
資源タイプ journal article
著者 Sakai, Chieko

× Sakai, Chieko

WEKO 4747
e-Rad 90734327
研究者総覧鳥取大学 100001235

Sakai, Chieko
ja-Kana サカイ, チエコ
en Sakai, Chieko
Search repository
Abe, Sunao

× Abe, Sunao

WEKO 17012

Abe, Sunao
ja-Kana アベ, スナオ
Search repository
Kouzuki, Minoru

× Kouzuki, Minoru

WEKO 17013

Kouzuki, Minoru
Search repository
Shimohiro, Hisashi

× Shimohiro, Hisashi

WEKO 3336
e-Rad 90583758
研究者総覧鳥取大学 100000167

Shimohiro, Hisashi
ja-Kana シモヒロ, ヒサシ
en Shimohiro, Hisashi
Search repository
Ota, Yoshie

× Ota, Yoshie

WEKO 17014

Ota, Yoshie
Search repository
Sakinada, Hironori

× Sakinada, Hironori

WEKO 17015

Sakinada, Hironori
Search repository
Takeuchi, Tatsuo

× Takeuchi, Tatsuo

WEKO 17016

Takeuchi, Tatsuo
Search repository
Okura, Tsuyoshi

× Okura, Tsuyoshi

WEKO 2790
e-Rad 80510073
研究者総覧鳥取大学 100000332

Okura, Tsuyoshi
ja-Kana オオクラ, ツヨシ
en Okura, Tsuyoshi
Search repository
Kasagi, Takeshi

× Kasagi, Takeshi

WEKO 17017

Kasagi, Takeshi
Search repository
Hanaki, Keiichi

× Hanaki, Keiichi

WEKO 545
e-Rad 20238041
研究者総覧鳥取大学 100000218

Hanaki, Keiichi
ja-Kana ハナキ, ケイイチ
en Hanaki, Keiichi
Search repository
Abe, Sunao

× Abe, Sunao

WEKO 17018

en Abe, Sunao
ja-Kana アベ, スナオ
Search repository
Kouzuki, Minoru

× Kouzuki, Minoru

WEKO 17019

en Kouzuki, Minoru
Search repository
Ota, Yoshie

× Ota, Yoshie

WEKO 17020

en Ota, Yoshie
Search repository
Sakinada, Hironori

× Sakinada, Hironori

WEKO 17021

en Sakinada, Hironori
Search repository
Takeuchi, Tatsuo

× Takeuchi, Tatsuo

WEKO 17022

en Takeuchi, Tatsuo
Search repository
Kasagi, Takeshi

× Kasagi, Takeshi

WEKO 17023

en Kasagi, Takeshi
Search repository
著者所属
値 Department of Adult and Elderly Nursing, School of Health Sciences, Tottori University Faculty of Medicine
著者所属
値 Marine Products Kimuraya Co., Ltd.
著者所属
値 Department of Biological Regulation, School of Health Sciences,Tottori University Faculty of Medicine
著者所属
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属
値 Clinical Laboratory Department, Hakuai Hospital
著者所属
値 Clinical Laboratory Department, Hakuai Hospital
著者所属
値 Department of Endocrinology and Metabolism, Hakuai Hospital
著者所属
値 Division of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
著者所属
値 Marine Products Kimuraya Co., Ltd.
著者所属
値 Department of Women’s and Children’s Family Nursing, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Adult and Elderly Nursing, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Marine Products Kimuraya Co., Ltd.
著者所属（英）
言語 en
値 Department of Biological Regulation, School of Health Sciences,Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Clinical Laboratory Department, Hakuai Hospital
著者所属（英）
言語 en
値 Clinical Laboratory Department, Hakuai Hospital
著者所属（英）
言語 en
値 Department of Endocrinology and Metabolism, Hakuai Hospital
著者所属（英）
言語 en
値 Division of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
著者所属（英）
言語 en
値 Marine Products Kimuraya Co., Ltd.
著者所属（英）
言語 en
値 Department of Women’s and Children’s Family Nursing, School of Health Sciences, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 [Background] Fucoidan is derived from seaweed widely used in Japanese cuisine, but little is known about its influence on glucose metabolism. To obtain information about the physiological effects of fucoidan on glucose metabolism, the digestive system, and the gustatory system controlling taste sensation in patients with type 2 diabetes, we conducted a randomized, double-blind, placebo-controlled study. [Methods] Thirty patients with type 2 diabetes on diet therapy were recruited from an outpatient clinic (22 men and 8 women aged 59.10 ± 13.24 years, body mass index: 25.18 ± 3.88, hemoglobin A1c: 7.04 ± 1.24%). They were divided into 2 groups and underwent 2 interventions with a 4-week interval. One group received fucoidan for 12 weeks (a daily 60 mL test beverage containing 1,620 mg of fucoidan) and then placebo (60 mL) for the subsequent 12-week period, while the order was reversed in the other group. Evaluation was performed just before and after each intervention. Taste sensitivity was measured for 5 basic tastes by the filter paper disk method and food intake was evaluated with a validated diet questionnaire. [Results] No adverse events occurred during the study period. Despite no change of the diet, stool frequency increased during fucoidan intake (from 7.78 ± 4.64/week in Week 1 to 9.15 ± 5.03/week in Week 5, P < 0.001), and it increased more in lean subjects. In 11 subjects whose stool frequency exceeded the mean value, the thresholds for sweet, salty, bitter and umami tastes were significantly reduced (enhancement of sensitivity) after fucoidan intake. In 14 subjects with normal HOMA-IR (homeostatic model assessment of insulin resistance, < 2.5), hemoglobin A1c decreased after fucoidan intake (from 6.73 ± 1.00 to 6.59 ± 1.00%, P < 0.05), as did the fasting plasma level of GLP-1 (glucagon-like peptide-1, from 6.42 ± 3.52 to 4.93 ± 1.88 pmol/L, P < 0.05). [Conclusion] Sustained fucoidan intake led to alterations of gastrointestinal function, including increased stool frequency and enhanced taste sensitivity, which could contribute to better control of diabetes.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 62, 号 1, p. 14-23, 発行日 2019-03-28
出版者
出版者 Tottori University Medical Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2019.03.003
権利
権利情報 Yonago Acta medica　編集委員会
情報源
関連名称 Yonago Acta Medica. 2019, 62(1), 14-23
関連サイト
識別子タイプ URI
関連識別子 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.003/_article/-char/en
関連名称 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.003/_article/-char/en
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
著者版フラグ
出版タイプ VoR
EISSN
値 1346-8049
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