Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2019-06-17 |
タイトル |
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言語 |
en |
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タイトル |
A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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主題 |
dietary fiber |
キーワード |
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主題Scheme |
Other |
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主題 |
fucoidan |
キーワード |
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主題Scheme |
Other |
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主題 |
glucagon-like peptide1 |
キーワード |
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主題Scheme |
Other |
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主題 |
taste sensitivity |
キーワード |
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主題Scheme |
Other |
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主題 |
type 2 diabetes mellitus |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
dietary fiber |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
fucoidan |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
glucagon-like peptide1 |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
taste sensitivity |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
type 2 diabetes mellitus |
資源タイプ |
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資源タイプ |
journal article |
著者 |
Sakai, Chieko
Abe, Sunao
Kouzuki, Minoru
Shimohiro, Hisashi
Ota, Yoshie
Sakinada, Hironori
Takeuchi, Tatsuo
Okura, Tsuyoshi
Kasagi, Takeshi
Hanaki, Keiichi
Abe, Sunao
Kouzuki, Minoru
Ota, Yoshie
Sakinada, Hironori
Takeuchi, Tatsuo
Kasagi, Takeshi
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著者所属 |
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Department of Adult and Elderly Nursing, School of Health Sciences, Tottori University Faculty of Medicine |
著者所属 |
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Marine Products Kimuraya Co., Ltd. |
著者所属 |
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Department of Biological Regulation, School of Health Sciences,Tottori University Faculty of Medicine |
著者所属 |
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Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
著者所属 |
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Clinical Laboratory Department, Hakuai Hospital |
著者所属 |
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Clinical Laboratory Department, Hakuai Hospital |
著者所属 |
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Department of Endocrinology and Metabolism, Hakuai Hospital |
著者所属 |
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Division of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine |
著者所属 |
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Marine Products Kimuraya Co., Ltd. |
著者所属 |
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Department of Women’s and Children’s Family Nursing, School of Health Sciences, Tottori University Faculty of Medicine |
著者所属(英) |
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en |
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Department of Adult and Elderly Nursing, School of Health Sciences, Tottori University Faculty of Medicine |
著者所属(英) |
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en |
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Marine Products Kimuraya Co., Ltd. |
著者所属(英) |
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en |
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Department of Biological Regulation, School of Health Sciences,Tottori University Faculty of Medicine |
著者所属(英) |
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en |
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Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine |
著者所属(英) |
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en |
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Clinical Laboratory Department, Hakuai Hospital |
著者所属(英) |
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en |
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Clinical Laboratory Department, Hakuai Hospital |
著者所属(英) |
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en |
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Department of Endocrinology and Metabolism, Hakuai Hospital |
著者所属(英) |
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en |
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Division of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine |
著者所属(英) |
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en |
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Marine Products Kimuraya Co., Ltd. |
著者所属(英) |
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en |
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Department of Women’s and Children’s Family Nursing, School of Health Sciences, Tottori University Faculty of Medicine |
抄録 |
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内容記述タイプ |
Other |
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内容記述 |
[Background] Fucoidan is derived from seaweed widely used in Japanese cuisine, but little is known about its influence on glucose metabolism. To obtain information about the physiological effects of fucoidan on glucose metabolism, the digestive system, and the gustatory system controlling taste sensation in patients with type 2 diabetes, we conducted a randomized, double-blind, placebo-controlled study. [Methods] Thirty patients with type 2 diabetes on diet therapy were recruited from an outpatient clinic (22 men and 8 women aged 59.10 ± 13.24 years, body mass index: 25.18 ± 3.88, hemoglobin A1c: 7.04 ± 1.24%). They were divided into 2 groups and underwent 2 interventions with a 4-week interval. One group received fucoidan for 12 weeks (a daily 60 mL test beverage containing 1,620 mg of fucoidan) and then placebo (60 mL) for the subsequent 12-week period, while the order was reversed in the other group. Evaluation was performed just before and after each intervention. Taste sensitivity was measured for 5 basic tastes by the filter paper disk method and food intake was evaluated with a validated diet questionnaire. [Results] No adverse events occurred during the study period. Despite no change of the diet, stool frequency increased during fucoidan intake (from 7.78 ± 4.64/week in Week 1 to 9.15 ± 5.03/week in Week 5, P < 0.001), and it increased more in lean subjects. In 11 subjects whose stool frequency exceeded the mean value, the thresholds for sweet, salty, bitter and umami tastes were significantly reduced (enhancement of sensitivity) after fucoidan intake. In 14 subjects with normal HOMA-IR (homeostatic model assessment of insulin resistance, < 2.5), hemoglobin A1c decreased after fucoidan intake (from 6.73 ± 1.00 to 6.59 ± 1.00%, P < 0.05), as did the fasting plasma level of GLP-1 (glucagon-like peptide-1, from 6.42 ± 3.52 to 4.93 ± 1.88 pmol/L, P < 0.05). [Conclusion] Sustained fucoidan intake led to alterations of gastrointestinal function, including increased stool frequency and enhanced taste sensitivity, which could contribute to better control of diabetes. |
書誌情報 |
Yonago Acta Medica
en : Yonago Acta Medica
巻 62,
号 1,
p. 14-23,
発行日 2019-03-28
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出版者 |
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出版者 |
Tottori University Medical Press |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
05135710 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00892882 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.33160/yam.2019.03.003 |
権利 |
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権利情報 |
Yonago Acta medica 編集委員会 |
情報源 |
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関連名称 |
Yonago Acta Medica. 2019, 62(1), 14-23 |
関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.003/_article/-char/en |
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関連名称 |
https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.003/_article/-char/en |
関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html |
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関連名称 |
http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html |
著者版フラグ |
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出版タイプ |
VoR |
EISSN |
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1346-8049 |