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アイテム
Protective Effects of Ipragliflozin, a Sodium-glucose Cotransporter 2 Inhibitor, on a Non-alcoholic Steatohepatitis Mouse Model
https://repository.lib.tottori-u.ac.jp/records/4766
https://repository.lib.tottori-u.ac.jp/records/476637bac9ca-a78b-4665-b638-db9d54ef8bc9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam62(1)_30.pdf (4.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2019-06-17 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Protective Effects of Ipragliflozin, a Sodium-glucose Cotransporter 2 Inhibitor, on a Non-alcoholic Steatohepatitis Mouse Model | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | ipragliflozin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | non-alcoholic steatohepatitis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | sodium-glucose cotransporter 2 inhibitor | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | ipragliflozin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | non-alcoholic steatohepatitis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | sodium-glucose cotransporter 2 inhibitor | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Yamane, Masafumi
× Yamane, Masafumi× Matono, Tomomitsu
WEKO
1986
× Okano, Jun-ichi× Nagahara, Ran× Matsuki, Yukako× Okamoto, Toshiaki× Miyoshi, Ken-ichi× Sugihara, Takaaki
WEKO
3446
× Nagahara, Takakazu× Koda, Masahiko× Isomoto, Hajime
WEKO
1082
× Yamane, Masafumi× Okano, Jun-ichi× Nagahara, Ran× Matsuki, Yukako× Okamoto, Toshiaki× Miyoshi, Ken-ichi× Nagahara, Takakazu× Koda, Masahiko |
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| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine/Hino Hospital | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine/Hino Hospital | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | [Background] The options for the treatment of nonalcoholic steatohepatitis (NASH) are limited. We examined the effects of ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, on the fatty liver Shionogi (FLS)-ob/ob mice, a non-alcoholic steatohepatitis mouse model. [Methods] FLS-ob/ob male mice were treated with vehicle (n = 10) and ipragliflozin (n = 8). Serum metabolic markers, histopathology of the liver, hepatic cholesterol and triglyceride levels and hepatic mRNA levels related to fibrosis, lipid metabolism and endoplasmic reticulum (ER) stress were compared between the two groups. [Results] The body weight and hepatic cholesterol and triglyceride levels were significantly decreased in the ipragliflozin group compared with the control group. Hepatic steatosis and fibrosis were significantly ameliorated by the treatment with ipragliflozin. Hepatic infiltration of macrophage, expression levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and hepatic mRNA levels of ER stress markers were not significantly modulated by the treatment with ipragliflozin. [Conclusion] Ipragliflozin can be a therapeutic option for patients with NASH. The precise mechanisms of action need to be clarified in future studies. | |||||||||||||||||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 62, 号 1, p. 30-35, 発行日 2019-03-28 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | Tottori University Medical Press | |||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 05135710 | |||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00892882 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.33160/yam.2019.03.005 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||||||||||||||||
| 情報源 | ||||||||||||||||||||||||
| 関連名称 | Yonago Acta Medica. 2019, 62(1), 30-35 | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.005/_article/-char/en | |||||||||||||||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.005/_article/-char/en | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| EISSN | ||||||||||||||||||||||||
| 値 | 1346-8049 | |||||||||||||||||||||||
