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Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model
https://repository.lib.tottori-u.ac.jp/records/4767
https://repository.lib.tottori-u.ac.jp/records/4767f85467bd-e1cc-4687-b8b4-7079675ed901
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam62(1)_36.pdf (3.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2019-06-17 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | endoplasmic reticulum stress | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | mouse model | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | nonalcoholic fatty liver disease | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | nonalcoholic steatohepatitis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | endoplasmic reticulum stress | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | mouse model | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | nonalcoholic fatty liver disease | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | nonalcoholic steatohepatitis | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Nagahara, Ran
× Nagahara, Ran× Matono, Tomomitsu
WEKO
1986
× Sugihara, Takaaki
WEKO
3446
× Matsuki, Yukako× Yamane, Masafumi× Okamoto, Toshiaki× Miyoshi, Kenichi× Nagahara, Takakazu× Okano, Jun-ichi× Koda, Masahiko× Isomoto, Hajime
WEKO
1082
× Nagahara, Ran× Matsuki, Yukako× Yamane, Masafumi× Okamoto, Toshiaki× Nagahara, Takakazu× Okano, Jun-ichi× Koda, Masahiko |
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| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属 | ||||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 著者所属（英） | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | [Background] Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is a chronic liver disease related to metabolic syndrome that can progress to liver cirrhosis. The involvement of the endoplasmic reticulum (ER) stress response in NAFLD progression and the roles played by activating factor 3 (ATF3) and the downstream nuclear protein 1 (NUPR1) are poorly understood. The aim of this study was to determine the gene expression profiles around the ATF3/NUPR1 axis in relation to the development of NAFLD using novel mouse models. [Methods] Fatty liver Shionogi (FLS) mice (n = 12) as a NAFLD model and FLS-ob/ob mice (n = 28) as a NASH model were fed a standard diet. The FLS mice were sacrificed at 24 weeks of age as a control, whereas the FLS-ob/ob mice were sacrificed at 24, 36, and 48 weeks of age. Hepatic steatosis, inflammation, and fibrosis were evaluated by biochemical, histological, and gene expression analyses. The expression levels of the ER-stress related genes Jun proto-oncogene (C-jun), Atf3, Nupr1, and C/EBP homologous protein (Chop) were measured in liver tissue. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. [Results] Control mice demonstrated hepatic steatosis alone without apparent fibrosis. On the other hand, FLS-ob/ob mice showed severe steatohepatitis at both 24 and 36 weeks of age and severe fibrosis at both 36 and 48 weeks of age. The expression levels of Atf3, Nupr-1, and C-jun significantly increased from 24 to 48 weeks of age in FLS-ob/ob mice compared with control mice. The expression level of Chop was already high in FLS mice and maintained similar levels in FLS-ob/ob mice; the expression level was consistent with the percentage of TUNEL-positive cells. [Conclusion] The ATF3/NUPR1 axis plays a pivotal role in NASH progression in association with C-jun and Chop and appears to induce apoptosis from early steatosis in the NASH model mice. | |||||||||||||||||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 62, 号 1, p. 36-46, 発行日 2019-03-28 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | Tottori University Medical Press | |||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 05135710 | |||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00892882 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.33160/yam.2019.03.006 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||||||||||||||||
| 情報源 | ||||||||||||||||||||||||
| 関連名称 | Yonago Acta Medica. 2019, 62(1), 36-46 | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.006/_article/-char/en | |||||||||||||||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.006/_article/-char/en | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| EISSN | ||||||||||||||||||||||||
| 値 | 1346-8049 | |||||||||||||||||||||||
