ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 62
  4. 1

Pharmacokinetic Drug Interaction Between Rosuvastatin and Tanjin in Healthy Volunteers and Rats

https://repository.lib.tottori-u.ac.jp/records/4772
https://repository.lib.tottori-u.ac.jp/records/4772
3925e8bb-abd1-443c-baf0-25225fc4e00b
名前 / ファイル ライセンス アクション
yam62(1)_77.pdf yam62(1)_77.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-17
タイトル
タイトル Pharmacokinetic Drug Interaction Between Rosuvastatin and Tanjin in Healthy Volunteers and Rats
言語 en
言語
言語 eng
キーワード
主題 absorption
キーワード
主題 drug interactions
キーワード
主題 herbal medicine
キーワード
主題 pharmacokinetics
キーワード
主題 rosuvastatin
キーワード
言語 en
主題 absorption
キーワード
言語 en
主題 drug interactions
キーワード
言語 en
主題 herbal medicine
キーワード
言語 en
主題 pharmacokinetics
キーワード
言語 en
主題 rosuvastatin
資源タイプ
資源タイプ journal article
著者 Yang, Jie

× Yang, Jie

WEKO 17098

Yang, Jie

Search repository
Hasegawa, Junichi

× Hasegawa, Junichi

WEKO 17099

Hasegawa, Junichi

Search repository
Endo, Yusuke

× Endo, Yusuke

WEKO 292
研究者総覧鳥取大学 100001268

Endo, Yusuke

ja-Kana エンドウ, ユウスケ

en Endo, Yusuke

Search repository
Iitsuka, Kazuhiko

× Iitsuka, Kazuhiko

WEKO 17100

Iitsuka, Kazuhiko

Search repository
Yamamoto, Miwa

× Yamamoto, Miwa

WEKO 4738
e-Rad 70353034
研究者総覧鳥取大学 100001160

Yamamoto, Miwa

ja-Kana ヤマモト, ミワ

en Yamamoto, Miwa

Search repository
Matsuda, Akiko

× Matsuda, Akiko

WEKO 17101

Matsuda, Akiko

Search repository
Yang, Jie

× Yang, Jie

WEKO 17102

en Yang, Jie

Search repository
Hasegawa, Junichi

× Hasegawa, Junichi

WEKO 17103

en Hasegawa, Junichi

Search repository
Iitsuka, Kazuhiko

× Iitsuka, Kazuhiko

WEKO 17104

en Iitsuka, Kazuhiko

Search repository
Matsuda, Akiko

× Matsuda, Akiko

WEKO 17105

en Matsuda, Akiko

Search repository
著者所属
値 Division of Pharmacology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 National Hospital Organization Yonago Medical Center
著者所属
値 Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital
著者所属
値 Division of Pharmacology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Department of Adult and Elderly Nursing, School of Health of Science, Tottori University Faculty of Medicine
著者所属
値 Faculty of Nursing, Nara Medical University
著者所属(英)
言語 en
値 Division of Pharmacology, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 National Hospital Organization Yonago Medical Center
著者所属(英)
言語 en
値 Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital
著者所属(英)
言語 en
値 Division of Pharmacology, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Department of Adult and Elderly Nursing, School of Health of Science, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Faculty of Nursing, Nara Medical University
抄録
内容記述タイプ Other
内容記述 [Background] Tanjin is an herbal medicine made from the root of salvia miltiorrhiza. It is predominantly given to arteriosclerotic patients as a supplement to ameliorate the clinical symptoms of cardiovascular diseases. In China, tanjin is used frequently in combination treatment for hypercholesterolemia. Thus, there is a high probability of combination of tanjin and statins in these arteriosclerotic patients. This study investigated the interaction between tanjin and rosuvastatin. [Methods] We performed a randomized single-blind, two-period crossover clinical trial on six healthy male volunteers. Volunteers were administered rosuvastatin with placebo or a tanjin-containing drug randomly. The blood samples were collected before drug administration, and at 0.5, 1, 1.5, 2, 4, 8, and 12 hours after administration. Lymphocytes were isolated from blood samples before and 12 hours after drug administration to measure mRNA. As an animal experiment, an in situ intestinal injection with portal vein sampling model was used to examine the interaction between tanjin and rosuvastatin during the absorption phase. Rosuvastatin or rosuvastatin combined with tanjin solution was injected into the intestine. After injection, blood from the portal vein was collected and the concentration of rosuvastatin was measured by LC/MS/MS analysis. A portion of the intestine and liver from the rats was collected and stored at -80°C for mRNA measurement. [Results] In the clinical trial, co-administration of tanjin decreased the maximum plasma concentration (Cmax) of rosuvastatin by 26.85% compared with rosuvastatin alone, and also decreased the area under the plasma concentration-time curve of rosuvastatin from 0 to 12 h (AUC0?12) by 19.43%. The relative expression of BCRP and OATP mRNA in human lymphocytes was increased by co-administration of tanjin. In the animal experiment, co-administration of tanjin extract reduced the concentration of rosuvastatin to 84.4, 64.4, and 50.0% at 15, 30, and 45 minutes, respectively. The tanjin-containing drug had a similar effect to tanjin extract. Furthermore, tanjin significantly reduced the absorption of rosuvastatin and the inhibitory effects lasted for at least 24 hours. Tanjin increased the relative expression of BCRP mRNA in the intestine, but it did not change the expression of OATP. Moreover, the concentration of rosuvastatin in the portal vein and systemic blood was reduced. In the liver, tanjin increased both BCRP and OATP mRNA expression, which was consistent with the results from human lymphocytes. [Conclusion] The clinical trial and animal experiment revealed that tanjin can significantly reduce the absorption of rosuvastatin. This interaction occurred, at least, at the absorption phase in the small intestine due to the enhanced efflux transport. Thus, as tanjin and rosuvastatin were found to interact, their combination needs to be paid attention to.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 62, 号 1, p. 77-84, 発行日 2019-03-28
出版者
出版者 Tottori University Medical Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2019.03.011
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta Medica. 2019, 62(1), 77-84
関連サイト
識別子タイプ URI
関連識別子 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.011/_article/-char/en
関連名称 https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.011/_article/-char/en
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html
著者版フラグ
出版タイプ VoR
EISSN
値 1346-8049
戻る
0
views
See details
Views

Versions

Ver.1 2023-08-02 07:17:32.300062
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3