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Nodal Merkel Cell Carcinoma in Head and Neck Lesions with an Unknown Primary: A Case Report in Light of the Literature
https://repository.lib.tottori-u.ac.jp/records/4798
https://repository.lib.tottori-u.ac.jp/records/4798c2451c12-797e-4c09-8416-642c8cb99adf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam62(3)_258.pdf (3.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-12-05 | |||||
| タイトル | ||||||
| タイトル | Nodal Merkel Cell Carcinoma in Head and Neck Lesions with an Unknown Primary: A Case Report in Light of the Literature | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | head and neck | |||||
| キーワード | ||||||
| 主題 | lymph node | |||||
| キーワード | ||||||
| 主題 | Merkel cell carcinoma | |||||
| キーワード | ||||||
| 主題 | neck lymph node dissection | |||||
| キーワード | ||||||
| 主題 | neuroendocrin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | head and neck | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lymph node | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Merkel cell carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neck lymph node dissection | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neuroendocrin | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ikeda, Ryoukichi
× Ikeda, Ryoukichi× Ohta, Nobuo× Fukaya, Sachiko× Shoji, Fumi× Suzuki, Takahiro× Noguchi, Naoya× Kakuta, Risako× Hayashi, Kazuhiko× Kida, Takayoshi× Murakami, Kazuhiro× Nakamura, Yasuhiro |
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| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pathology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Otolaryngology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Laboratory of Gastrointestinal Regenerative Medicine, Okayama University of Science | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pathology, Tohoku Medical and Pharmaceutical University | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pathology, Tohoku Medical and Pharmaceutical University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. To diagnose nodal MCC with an unknown primary disease is challenging, and it has to be separated from other nodal metastatic neoplasms. We report a unique case of nodal MCC in head and neck lesions with an unknown primary. A 70-year-old woman was admitted to our department with a right submandibular mass. Fine needle aspiration biopsy was performed and indicated malignancy. F-18-fluorodeoxyglucose positron emission tomography (PET) demonstrated abnormal accumulation in the right submandibular lymph node, right palatine tonsil, and right thyroid gland. For diagnostics and treatment, bilateral selective neck lymph node dissection, right tonsillectomy, and right thyroidectomy were performed. Histopathological examination revealed that most parts of the submandibular lymph node were occupied by diffuse sheets of tumor cells. Contrary to our expectation, malignant cells were not detected in the right palatine tonsil and right thyroid. Immunohistochemistry demonstrated a marked positive reaction for AE1/AE3, chromogranin A, synaptophysin, cytokeratin 20 (CK20) and CD56 and a negative reaction for vimentin, leucocyte common antigen (LCA), thyroid transcription factor-1 (TTF1) and cytokeratin 7 (CK7) in the tumor cells. Immunostaining of Merkel cell polyomavirus-large T antigen (MCPyV-LT) showed a positive reaction and MCPyV-positive MCCs were assessed by PCR analysis, demonstrating that viral copy number was 12.8 copies per cell. These histological findings confirmed the diagnosis of Merkel cell carcinoma of the lymph node. In cases of tumors in the lymph node with a neuroendocrine appearance in head and neck lesions, it is necessary to eliminate the possibility of metastasis from MCC. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 62, 号 3, p. 258-262, 発行日 2019-09-13 |
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| 雑誌内区分 | ||||||
| 値 | Patient Report | |||||
| 出版者 | ||||||
| 出版者 | Tottori University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2019.09.003 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Ikeda R, Ohta N, Fukaya S, Shoji F, Suzuki T, Noguchi N, et al. Nodal Merkel Cell Carcinoma in Head and Neck Lesions with an Unknown Primary: A Case Report in Light of the Literature. Yonago Acta Medica. 2019;62:258-262. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-3/62-3contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam62-3/62-3contents.html | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yam/62/3/62_2019.09.003/_article/ | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yam/62/3/62_2019.09.003/_article/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
