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Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis
https://repository.lib.tottori-u.ac.jp/records/4809
https://repository.lib.tottori-u.ac.jp/records/4809ae5e6e86-406e-40a5-86cd-5153f4eaa630
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam61(1)_27.pdf (548.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-06-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | HLA | |||||||||
| キーワード | ||||||||||
| 主題 | inflammatory bowel disease | |||||||||
| キーワード | ||||||||||
| 主題 | Japanese | |||||||||
| キーワード | ||||||||||
| 主題 | ulcerative colitis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | HLA | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | inflammatory bowel disease | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Japanese | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | ulcerative colitis | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Iwamoto, Taku
× Iwamoto, Taku× Yashima, Kazuo× Morio, Keiko× Ueda, Naoki× Ikebuchi, Yuichiro× Kawaguchi, Koichiro
WEKO
1397
× Harada, Kenichi× Isomoto, Hajime× Iwamoto, Taku× Morio, Keiko× Ueda, Naoki× Ikebuchi, Yuichiro |
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| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 【Background】 The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn’s disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. 【Methods】 In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined. 【Results】 Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons (P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients. 【Conclusion】 These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients. | |||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 61, 号 1, p. 27-32, 発行日 2018-03-28 |
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| 出版者 | ||||||||||
| 出版者 | Tottori University Faculty of Medicine | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 05135710 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00892882 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.33160/yam.2018.03.004 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||
| 情報源 | ||||||||||
| 関連名称 | Yonago Acta Medica. 2018, 61(1), 27-32 | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-1/61-1contents.html | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| EISSN | ||||||||||
| 値 | 1346-8049 | |||||||||
