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The Utility of the Combined Use of 123I-FP-CIT and 123I-MIBG Myocardial Scintigraphy in Differentiating Parkinson’s Disease from Other Parkinsonian Syndromes
https://repository.lib.tottori-u.ac.jp/records/4822
https://repository.lib.tottori-u.ac.jp/records/48229ca7f5da-a0b2-40f6-8c78-121e06984723
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam61(2)_117.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | The Utility of the Combined Use of 123I-FP-CIT and 123I-MIBG Myocardial Scintigraphy in Differentiating Parkinson’s Disease from Other Parkinsonian Syndromes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | 123I-FP-CIT | |||||
| キーワード | ||||||
| 主題 | 123I-MIBG | |||||
| キーワード | ||||||
| 主題 | Parkinson’s disease | |||||
| キーワード | ||||||
| 主題 | combined analysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | 123I-FP-CIT | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | 123I-MIBG | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Parkinson’s disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | combined analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsusue, Eiji
× Matsusue, Eiji× Fujihara, Yoshio× Tanaka, Kenichiro× Aozasa, Yuki× Shimoda, Manabu× Nakayasu, Hiroyuki× Nakamura, Kazuhiko× Ogawa, Toshihide× Fujihara, Yoshio× Aozasa, Yuki× Shimoda, Manabu× Nakayasu, Hiroyuki× Nakamura, Kazuhiko× Ogawa, Toshihide |
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| 著者所属 | ||||||
| 値 | Department of Radiology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Radiology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Neurology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Neurology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Neurology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Neurology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Radiology, Tottori Prefectural Central Hospital | |||||
| 著者所属 | ||||||
| 値 | Division of Radiology, Department of Pathophysiological Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 【Background】123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy and 123I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) provide specific information that distinguish Parkinson’s disease (PD) from parkinsonian syndromes other than PD (non-PD), including atypical parkinsonian disorder (APD) and non-PD other than APD (nPD-nAPD). The purpose of this study was to determine whether combining DAT-SPECT and MIBG myocardial scintigraphy using multiparametric scoring system (MSS) could improve diagnostic test accuracy in discriminating PD from APD or discriminating PD from nPD-nAPD. 【Methods】A total of 52 patients, including 36 PD, eight APD and eight nPD-nAPD, underwent both MIBG myocardial scintigraphy and DAT-SPECT, were evaluated. The heart-to-mediastinum (H/M) ratios (early and delayed), washout-rate (WR), the average (Ave) and asymmetry index (AI) of specific binding ratio (SBR) were calculated. Cutoff values were determined, using ROC analysis, for discriminating PD from APD and for discriminating PD from nPD-nAPD, on five parameters. All cases were scored as either 1 (PD) or 0 (nPD-nAPD or APD) for each parameter according to its threshold in each discrimination. These individual scores were summed for each case, yielding a combined score to obtain a cutoff value for the MSS in each discrimination. 【Results】For discriminating PD from nPD-nAPD, the highest accuracy was 80% at a cutoff value of 19% for the WR and a cut off value of 2 improved diagnostic accuracy to 84% for MSS. For discriminating PD from APD, the highest accuracy was 86% at a cutoff value of 2.8 for the H/M ratio (late) and a cut off value of 2 showed diagnostic accuracy of 86% for MSS. 【Conclusion】A MSS has comparable or better accuracy compared to each parameter of MIBG myocardial scintigraphy and DAT-SPECT in distinguishing PD from nPD-nAPD or distinguishing PD from APD. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 61, 号 2, p. 117-127, 発行日 2018-06-18 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2018.06.004 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2018, 61(2), 117-127 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
