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Establishment of a Novel In Situ Rat Model for Direct Measuring of Intestinal Drug Absorption: Confirmation of Inhibitory Effects of Daijokito on the Absorption of Ranitidine
https://repository.lib.tottori-u.ac.jp/records/4834
https://repository.lib.tottori-u.ac.jp/records/4834680f4179-4d32-4383-b14e-ac948c439527
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam61(4)_192.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-01-09 | |||||
| タイトル | ||||||
| タイトル | Establishment of a Novel In Situ Rat Model for Direct Measuring of Intestinal Drug Absorption: Confirmation of Inhibitory Effects of Daijokito on the Absorption of Ranitidine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | absorption | |||||
| キーワード | ||||||
| 主題 | daijokito | |||||
| キーワード | ||||||
| 主題 | portal vein sampling | |||||
| キーワード | ||||||
| 主題 | ranitidine | |||||
| キーワード | ||||||
| 主題 | rat model | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | absorption | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | daijokito | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | portal vein sampling | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ranitidine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | rat model | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Qian, Weibin
× Qian, Weibin× Hasegawa, Junichi× Yang, Jie× Endo, Yusuke× Miake, Junichiro× Qian, Weibin× Yang, Jie |
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| 著者所属 | ||||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center | |||||
| 著者所属 | ||||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital | |||||
| 著者所属 | ||||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital | |||||
| 著者所属（英） | ||||||
| 言語 | en | |||||
| 値 | Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 【Background】 Daijokito (DJKT), a classical traditional Kampo and Chinese medicine, has been used to treat acute pancreatitis in China. In our previous study, DJKT was found to reduce the area under the plasma concentration-time curve (AUC) of ranitidine in humans. Therefore, we established a novel rat model to examine the direct absorption of ranitidine after daijokito administration. 【Methods】 An in situ intestinal injection with portal vein sampling (IIPS) model was created to determine the rate of intestinal drug absorption. Rats were divided into two groups: the ranitidine group (R, n = 6) or the ranitidine and daijokito group (RD, n = 6). Blood was collected after intestinal injection of drugs. After the experiment, the concentrations of ranitidine were measured by LC/MS/MS analysis. 【Results】 The concentrations of ranitidine increased linearly with time in both groups. Compared with the R group, the concentrations of ranitidine in RD group significantly decreased throughout the experiment. 【Conclusion】 Co-administration of ranitidine with DJKT resulted in significant decreases in intestinal absorption in rats. The reduction of the systemic ranitidine concentration by co-administration of DJKT may be due, at least in part, to the inhibition of intestinal absorption of ranitidine. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 61, 号 4, p. 192-196, 発行日 2018-12-27 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2018.12.001 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2018, 61(4), 192-196 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-4/61-4contents.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam61-4/61-4contents.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
