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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 61
  4. 4

Establishment of a Novel In Situ Rat Model for Direct Measuring of Intestinal Drug Absorption: Confirmation of Inhibitory Effects of Daijokito on the Absorption of Ranitidine

https://repository.lib.tottori-u.ac.jp/records/4834
https://repository.lib.tottori-u.ac.jp/records/4834
680f4179-4d32-4383-b14e-ac948c439527
名前 / ファイル ライセンス アクション
yam61(4)_192.pdf yam61(4)_192.pdf (1.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-01-09
タイトル
タイトル Establishment of a Novel In Situ Rat Model for Direct Measuring of Intestinal Drug Absorption: Confirmation of Inhibitory Effects of Daijokito on the Absorption of Ranitidine
言語 en
言語
言語 eng
キーワード
主題 absorption
キーワード
主題 daijokito
キーワード
主題 portal vein sampling
キーワード
主題 ranitidine
キーワード
主題 rat model
キーワード
言語 en
主題 absorption
キーワード
言語 en
主題 daijokito
キーワード
言語 en
主題 portal vein sampling
キーワード
言語 en
主題 ranitidine
キーワード
言語 en
主題 rat model
資源タイプ
資源タイプ journal article
著者 Qian, Weibin

× Qian, Weibin

WEKO 17394

Qian, Weibin

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Hasegawa, Junichi

× Hasegawa, Junichi

WEKO 597
e-Rad 60189529

Hasegawa, Junichi

en Hasegawa, Junichi

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Yang, Jie

× Yang, Jie

WEKO 17395

Yang, Jie

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Endo, Yusuke

× Endo, Yusuke

WEKO 292
研究者総覧鳥取大学 100001268

Endo, Yusuke

en Endo, Yusuke

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Miake, Junichiro

× Miake, Junichiro

WEKO 4730
e-Rad 40372677
研究者総覧鳥取大学 100000259

Miake, Junichiro

en Miake, Junichiro

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Qian, Weibin

× Qian, Weibin

WEKO 17396

en Qian, Weibin

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Yang, Jie

× Yang, Jie

WEKO 17397

en Yang, Jie

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著者所属
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
著者所属
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center
著者所属
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital
著者所属
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
著者所属(英)
言語 en
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center
著者所属(英)
言語 en
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
著者所属(英)
言語 en
値 Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital
著者所属(英)
言語 en
値 Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 【Background】 Daijokito (DJKT), a classical traditional Kampo and Chinese medicine, has been used to treat acute pancreatitis in China. In our previous study, DJKT was found to reduce the area under the plasma concentration-time curve (AUC) of ranitidine in humans. Therefore, we established a novel rat model to examine the direct absorption of ranitidine after daijokito administration. 【Methods】 An in situ intestinal injection with portal vein sampling (IIPS) model was created to determine the rate of intestinal drug absorption. Rats were divided into two groups: the ranitidine group (R, n = 6) or the ranitidine and daijokito group (RD, n = 6). Blood was collected after intestinal injection of drugs. After the experiment, the concentrations of ranitidine were measured by LC/MS/MS analysis. 【Results】 The concentrations of ranitidine increased linearly with time in both groups. Compared with the R group, the concentrations of ranitidine in RD group significantly decreased throughout the experiment. 【Conclusion】 Co-administration of ranitidine with DJKT resulted in significant decreases in intestinal absorption in rats. The reduction of the systemic ranitidine concentration by co-administration of DJKT may be due, at least in part, to the inhibition of intestinal absorption of ranitidine.
書誌情報 Yonago Acta Medica
en : Yonago Acta Medica

巻 61, 号 4, p. 192-196, 発行日 2018-12-27
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05135710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.33160/yam.2018.12.001
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta Medica. 2018, 61(4), 192-196
関連サイト
識別子タイプ URI
関連識別子 http://www.lib.tottori-u.ac.jp/yam/yam/yam61-4/61-4contents.html
関連名称 http://www.lib.tottori-u.ac.jp/yam/yam/yam61-4/61-4contents.html
著者版フラグ
出版タイプ VoR
EISSN
値 1346-8049
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