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A Histopathologic Study of the Human Skin in the Early Stage After a Tick Bite: A Special Reference to Cutaneous Tissue Reaction to the Cement Substance of Tick Saliva
https://repository.lib.tottori-u.ac.jp/records/4870
https://repository.lib.tottori-u.ac.jp/records/48707a6d5e69-2796-4b03-b0f3-dae9da1959e6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam60(3)_186.pdf (8.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | A Histopathologic Study of the Human Skin in the Early Stage After a Tick Bite: A Special Reference to Cutaneous Tissue Reaction to the Cement Substance of Tick Saliva | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | cement substance | |||||
| キーワード | ||||||
| 主題 | cutaneous inflammatory reaction | |||||
| キーワード | ||||||
| 主題 | histopathology | |||||
| キーワード | ||||||
| 主題 | tick bite | |||||
| キーワード | ||||||
| 主題 | tick saliva | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cement substance | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cutaneous inflammatory reaction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | histopathology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tick bite | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tick saliva | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Mihara, Motoyuki
× Mihara, Motoyuki× Mihara, Motoyuki |
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| 著者所属 | ||||||
| 値 | Mihara Dermatology Clinic, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Ixodidae family of hard ticks has cement-producing and non-cement-producing species. Involved skins of four patients bitten by cement-producing ticks and two by non-cement-producing ticks were histopathologically examined. Those of the latter two patients were also studied immunohistochemically to characterize the infiltrating inflammatory cells. In patients with cement-producing ticks, the cement substance was observed as external cement or outer zone of internal cement, respectively. Coagulative necrosis was present in the epidermis in one patient and from the epidermis to the dermis in another patient. Epidermal cells were damaged in the remaining two patients. Despite these severe tissue damages, the cutaneous inflammatory reaction in all four patients was very mild. In contrast, the patients bitten by non-cement-producing ticks had severe cutaneous inflammatory reaction. In addition to caseous necrosis-like change in the entrance site of the inserted mouthparts, extensive interstitial lymphohistiocytic infiltrate was present diffusely from the dermis to the subcutaneous tissue. In one of the patients coagulative necrosis was present from the dermis to the subcutaneous tissue. Immunohistochemically, the infiltrating lymphocytes were T-cell dominant and mixed moderately with B-cells. Pathogenetically, the cutaneous inflammatory reaction is only mild in the skins involved by the cement-producing ticks, perhaps because inflammatory reaction in the host skin is suppressed by antiinflammatory and immunosuppressive substances contained in tick’s saliva in order to prevent position of their mouthparts fixed to the host skin from rejection of the host until finishing their engorgement. In contrast, the cutaneous inflammatory reaction induced by the non-cement-producing ticks is severe, possibly because these ticks have no antiinflammatory and immunosuppressive substances in their saliva, and because their saliva is much more injurious than that of the cement-producing ticks. | |||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 60, 号 3, p. 186-199, 発行日 2017-09-15 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05135710 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33160/yam.2017.09.009 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta Medica. 2017, 60(3), 186-199 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-186.pdf | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-186.pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| EISSN | ||||||
| 値 | 1346-8049 | |||||
