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Prognostic Factors for Post Recurrence Survival in Resected Pathological Stage I Non-small Cell Lung Cancer
https://repository.lib.tottori-u.ac.jp/records/4874
https://repository.lib.tottori-u.ac.jp/records/48743250ceaf-2f68-4a8b-ad41-59585d0fd6e7
| 名前 / ファイル | ライセンス | アクション |
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yam60(4)_213.pdf (624.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-06-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Prognostic Factors for Post Recurrence Survival in Resected Pathological Stage I Non-small Cell Lung Cancer | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | epidermal growth factor receptor tyrosine kinase inhibitors | |||||||||
| キーワード | ||||||||||
| 主題 | non-small cell lung cancer | |||||||||
| キーワード | ||||||||||
| 主題 | post recurrecurrence | |||||||||
| キーワード | ||||||||||
| 主題 | prognostic factor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | epidermal growth factor receptor tyrosine kinase inhibitors | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | non-small cell lung cancer | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | post recurrecurrence | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | prognostic factor | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Kubouchi, Yasuaki
× Kubouchi, Yasuaki× Kidokoro, Yoshiteru× Ohno, Takashi× Yurugi, Yohei× Wakahara, Makoto× Haruki, Tomohiro× Nakamura, Hiroshige
WEKO
2488
× Kubouchi, Yasuaki× Ohno, Takashi× Yurugi, Yohei |
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| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 著者所属（英） | ||||||||||
| 言語 | en | |||||||||
| 値 | Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | [Background]Recurrence of lung cancer after surgical resection is a major obstacle in the cure and long-term survival of patients and has become the most common cause of death. However, prognostic factors and efficacy of therapy after recurrence remain controversial. We evaluated the prognostic factors of post recurrence survival (PRS) in patients of resected stage I non-small cell lung cancer (NSCLC). [Methods]Of the 551 patients who underwent surgery for stage I NSCLC between 2005 and 2013, we reviewed 89 (16.2%) patients who had recurrence. We examined PRS using the Kaplan?Meier method and multivariate Cox regression analyses. [Results]The median follow-up period after recurrence was 21.0 months. The median recurrence free interval (RFI) was 16.8 months. The 1-year PRS and 3-year PRS were 65.6% and 44.7%, respectively. Multivariate analysis revealed that size of primary lesion > 25 mm (P = 0.048), RFI ? 17 months (P = 0.048) and no treatment for recurrence (P < 0.001) were independent poor-prognosis factors of PRS. We further examined PRS in 66 patients who underwent any post recurrence therapy. For the patients who underwent treatment after recurrence, bone metastasis (P = 0.025) and treatment without epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) (P = 0.049) were independent poor prognostic factors. [Conclusion]PRS may be associated with characteristics of a recurrent lesion, including the biology of the recurrent tumor, RFI, recurrent site, the treatment for recurrence, rather than characteristics of primary lesion. Although further validation is needed, this information is important for the design of clinical trials for post-recurrence therapy. | |||||||||
| 書誌情報 |
Yonago Acta Medica en : Yonago Acta Medica 巻 60, 号 4, p. 213-219, 発行日 2018-02-05 |
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| 出版者 | ||||||||||
| 出版者 | Tottori University Faculty of Medicine | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 05135710 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00892882 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.33160/yam.2017.12.001 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||||||
| 情報源 | ||||||||||
| 関連名称 | Yonago Acta Medica. 2017,60(4),213-219 | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam60-4/60-4contents.html | |||||||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam60-4/60-4contents.html | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| EISSN | ||||||||||
| 値 | 1346-8049 | |||||||||
