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Increased B7-H1 and B7-H4 Expressions on Circulating Monocytes and Tumor-Associated Macrophages are Involved in Immune Evasion in Patients with Gastric Cancer
https://repository.lib.tottori-u.ac.jp/records/4996
https://repository.lib.tottori-u.ac.jp/records/4996a34cb54d-cb16-4e67-8727-96d8bfe844ac
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
54_001-010.pdf (508.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Increased B7-H1 and B7-H4 Expressions on Circulating Monocytes and Tumor-Associated Macrophages are Involved in Immune Evasion in Patients with Gastric Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | B7-H1 | |||||
| キーワード | ||||||
| 主題 | B7-H4 | |||||
| キーワード | ||||||
| 主題 | gastric cancer | |||||
| キーワード | ||||||
| 主題 | macrophage | |||||
| キーワード | ||||||
| 主題 | monocyte | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | B7-H1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | B7-H4 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | gastric cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | macrophage | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | monocyte | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsunaga, Tomoyuki
× Matsunaga, Tomoyuki× Saito, Hiroaki× Ikeguchi, Masahide |
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| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Expression of the costimulatory molecule B7-H4, a member of the inhibitory B7 family, has been reported to be upregulated on tumor-associated macrophages, and this overexpression may be involved in immune evasion in cancer patients. The present study was designed to investigate B7-H4 expression on monocytes/macrophages and its relationship with immune evasion in gastric cancer patients. B7-H4 expression on circulating monocytes and tumor-associated macrophages was evaluated by multicolor flow cytometry. Carboxyfluorescein succinimidyl ester proliferation assays and quantitative interferon-gamma enzyme-linked immunosorbent assays were carried out to determine the inhibitory effect of B7-H4+ monocytes on CD4+ T cells. B7-H4 expression on circulating monocytes was upregulated and these B7-H4+ monocytes showed immunosuppressive properties. B7-H4 expression was closely related to the depth of invasion, as well as the presence of lymphatic and venous invasion. There were significant correlations between B7-H4 expression and B7-H1 or HLA-DR expression on monocytes/macrophages in gastric cancer patients. B7-H4 expression was remarkably upregulated in gastric cancer tissues compared with peripheral blood samples. Complete surgical removal of the tumor decreased B7-H4 expression on circulating monocytes from gastric cancer patients. Cocultures of gastric cancer cell lines and monocytes led to upregulation of B7-H4 expression on monocytes. Increased B7-H4 expression on circulating monocytes and tumor-associated macrophages may be one of the key mechanisms responsible for immune evasion by tumors in gastric cancer. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 54, 号 1, p. 1-10, 発行日 2011-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2011, 54(1), 1-10 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_001-010.html | |||||
| 関連名称 | http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_001-010.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
