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The Effects of Olmesartan and Alfacalcidol on Renoprotection and klotho Gene Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats
https://repository.lib.tottori-u.ac.jp/records/5002
https://repository.lib.tottori-u.ac.jp/records/50024f558dfa-b2bb-4aa5-bae3-abefe5145510
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
54_049-058.pdf (625.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | The Effects of Olmesartan and Alfacalcidol on Renoprotection and klotho Gene Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | angiotensin II receptor blocker | |||||
| キーワード | ||||||
| 主題 | chronic renal failure | |||||
| キーワード | ||||||
| 主題 | fibroblast growth factor 23 | |||||
| キーワード | ||||||
| 主題 | klotho gene | |||||
| キーワード | ||||||
| 主題 | vitamin D | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | angiotensin II receptor blocker | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | chronic renal failure | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fibroblast growth factor 23 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | klotho gene | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | vitamin D | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukui, Takeaki
× Fukui, Takeaki× Munemura, Chishio× Maeta, Satoko× Ishida, Chihiro× Murawaki, Yoshikazu× Fukui, Takeaki× Maeta, Satoko× Ishida, Chihiro |
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| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Recently, an angiotensin inhibitor has been shown to upregulate the klotho mRNA level in chronic renal failure. In addition, the administration of vitamin D has been reported to improve the mortality of patients with chronic renal failure. In this study, we examined the effects of an angiotensin inhibitor and/or vitamin D on the progression of chronic renal failure by using male 5/6 nephrectomized (5/6Nx) spontaneously hypertensive rats. Male 5/6Nx spontaneously hypertensive rats were assigned to 4 groups as follows: 5/6Nx group, 5/6Nx rats; Alf group, 5/6Nx rats administered alfacalcidol (0.2 μg/kg/day); Olm group, 5/6Nx rats administered olmesartan (15 mg/kg/day); Alf + Olm group, 5/6Nx rats administered alfacalcidol (0.2 μg/kg/day) and olmesartan (15 mg/kg/day). These drugs were administered for 12 weeks. Systolic blood pressure in the Alf, Olm and Alf + Olm groups were significantly decreased relative to that in the 5/6Nx group during the 12-week experimental period. As a result, all treated groups showed renoprotection based on improvement of the systolic blood pressure, urinary protein excretion and histological renal fibrosis. Combination therapy of alfacalcidol and olmesartan was more effective than either alfacalcidol or olmesartan alone. Expression of klotho mRNA was significantly upregulated in the Alf + Olm group in comparison with in the 5/6Nx group. Serum levels of fibroblast growth factor 23 in the Alf group and the Alf + Olm group were significantly higher than those in the 5/6Nx group and the Olm group. In conclusion, the combination of Olm and Alf inhibited the progression of renal damage in the 5/6Nx group through the strong antihypertensive effect as well as the upregulation of the klotho gene. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 54, 号 3, p. 49-58, 発行日 2011-09 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2011, 54(3), 49-58 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam54-3/yam54_049-058.html | |||||
| 関連名称 | https://www.lib.tottori-u.ac.jp/yam/yam54-3/yam54_049-058.html | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
