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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 54
  4. 3

The Effects of Olmesartan and Alfacalcidol on Renoprotection and klotho Gene Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats

https://repository.lib.tottori-u.ac.jp/records/5002
https://repository.lib.tottori-u.ac.jp/records/5002
4f558dfa-b2bb-4aa5-bae3-abefe5145510
名前 / ファイル ライセンス アクション
54_049-058.pdf 54_049-058.pdf (625.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル The Effects of Olmesartan and Alfacalcidol on Renoprotection and klotho Gene Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats
言語 en
言語
言語 eng
キーワード
主題 angiotensin II receptor blocker
キーワード
主題 chronic renal failure
キーワード
主題 fibroblast growth factor 23
キーワード
主題 klotho gene
キーワード
主題 vitamin D
キーワード
言語 en
主題 angiotensin II receptor blocker
キーワード
言語 en
主題 chronic renal failure
キーワード
言語 en
主題 fibroblast growth factor 23
キーワード
言語 en
主題 klotho gene
キーワード
言語 en
主題 vitamin D
資源タイプ
資源タイプ journal article
著者 Fukui, Takeaki

× Fukui, Takeaki

WEKO 18320

Fukui, Takeaki

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Munemura, Chishio

× Munemura, Chishio

WEKO 2346
研究者総覧鳥取大学 100000438

Munemura, Chishio

en Munemura, Chishio

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Maeta, Satoko

× Maeta, Satoko

WEKO 18321

Maeta, Satoko

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Ishida, Chihiro

× Ishida, Chihiro

WEKO 18322

Ishida, Chihiro

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Murawaki, Yoshikazu

× Murawaki, Yoshikazu

WEKO 2381
e-Rad 90144659

Murawaki, Yoshikazu

en Murawaki, Yoshikazu

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Fukui, Takeaki

× Fukui, Takeaki

WEKO 18323

en Fukui, Takeaki

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Maeta, Satoko

× Maeta, Satoko

WEKO 18324

en Maeta, Satoko

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Ishida, Chihiro

× Ishida, Chihiro

WEKO 18325

en Ishida, Chihiro

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著者所属
値 Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Recently, an angiotensin inhibitor has been shown to upregulate the klotho mRNA level in chronic renal failure. In addition, the administration of vitamin D has been reported to improve the mortality of patients with chronic renal failure. In this study, we examined the effects of an angiotensin inhibitor and/or vitamin D on the progression of chronic renal failure by using male 5/6 nephrectomized (5/6Nx) spontaneously hypertensive rats. Male 5/6Nx spontaneously hypertensive rats were assigned to 4 groups as follows: 5/6Nx group, 5/6Nx rats; Alf group, 5/6Nx rats administered alfacalcidol (0.2 μg/kg/day); Olm group, 5/6Nx rats administered olmesartan (15 mg/kg/day); Alf + Olm group, 5/6Nx rats administered alfacalcidol (0.2 μg/kg/day) and olmesartan (15 mg/kg/day). These drugs were administered for 12 weeks. Systolic blood pressure in the Alf, Olm and Alf + Olm groups were significantly decreased relative to that in the 5/6Nx group during the 12-week experimental period. As a result, all treated groups showed renoprotection based on improvement of the systolic blood pressure, urinary protein excretion and histological renal fibrosis. Combination therapy of alfacalcidol and olmesartan was more effective than either alfacalcidol or olmesartan alone. Expression of klotho mRNA was significantly upregulated in the Alf + Olm group in comparison with in the 5/6Nx group. Serum levels of fibroblast growth factor 23 in the Alf group and the Alf + Olm group were significantly higher than those in the 5/6Nx group and the Olm group. In conclusion, the combination of Olm and Alf inhibited the progression of renal damage in the 5/6Nx group through the strong antihypertensive effect as well as the upregulation of the klotho gene.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 54, 号 3, p. 49-58, 発行日 2011-09
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2011, 54(3), 49-58
関連サイト
識別子タイプ URI
関連識別子 https://www.lib.tottori-u.ac.jp/yam/yam54-3/yam54_049-058.html
関連名称 https://www.lib.tottori-u.ac.jp/yam/yam54-3/yam54_049-058.html
著者版フラグ
出版タイプ VoR
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