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Functional Polymorphisms in the Promoter Regions of Matrix Metalloproteinase-2, -3, -7, -9 and TNF-alpha Genes, and the Risk of Colorectal Neoplasm in Japanese
https://repository.lib.tottori-u.ac.jp/records/5024
https://repository.lib.tottori-u.ac.jp/records/5024bc398d20-1605-4735-a1a0-11017cfde8b9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
52_047-056.pdf (140.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Functional Polymorphisms in the Promoter Regions of Matrix Metalloproteinase-2, -3, -7, -9 and TNF-alpha Genes, and the Risk of Colorectal Neoplasm in Japanese | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | colorectal neoplasm | |||||
| キーワード | ||||||
| 主題 | gene analysis | |||||
| キーワード | ||||||
| 主題 | matrix metalloproteinase | |||||
| キーワード | ||||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 主題 | tumor necrosis factor-alpha | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | colorectal neoplasm | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | gene analysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | matrix metalloproteinase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tumor necrosis factor-alpha | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ohtani, Hideyuki
× Ohtani, Hideyuki× Maeda, Naoto× Murawaki, Yoshikazu× Ohtani, Hideyuki |
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| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Colorectal carcinogenesis involves environmental factors and genetic predispositions. Recent studies have suggested the associations between colorectal neoplasm and functional polymorphism of matrix metalloproteinases (MMPs) and cytokine genes. In this study, we analyzed polymorphisms of MMPs and tumor necrosis factor (TNF)-alpha genes, focusing on the susceptibility to colorectal neoplasm and the tumor progression. The subjects were 186 patients (95 men and 91 women) who underwent total colonoscopy, and were classified into cancer, adenoma and non-neoplasm (control) groups of 47, 72 and 67 patients, respectively. The polymorphisms at the MMP-2 ?1306C/T, MMP-3 ?1171 5A/6A, MMP-7 ?181A/G, MMP-9 ?1562C/T and TNF-alpha ?308G/A loci were analyzed. Regarding background factors, significant differences were found in the age, sex ratio and alcohol-drinking and cigarette-smoking histories in the adenoma and cancer groups, compared to those in the control group. On these factors-adjusted logistic regression analysis of polymorphisms and disease susceptibility, no significant difference was noted in the frequency of any polymorphism in the adenoma and cancer groups, compared to those in the control group. The analysis of the involvement of polymorphisms in tumor progression in the adenoma and cancer groups revealed that the odds ratio for the MMP-3 5A allele was significantly higher in the cancer group (2.74; 95% confidence interval = 1.11?6.74, P = 0.02). The polymorphisms of MMP genes and TNF-alpha genes were not associated with the susceptibility to colorectal neoplasm, but the involvement of the MMP-3 5A allele in the progression of adenoma to cancer was suggested. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 52, 号 1, p. 47-56, 発行日 2009-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2009, 52(1), 47-56 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
