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Helminth Infections Prevent Autoimmune Diseases through Th2-Type Immune Response
https://repository.lib.tottori-u.ac.jp/records/5030
https://repository.lib.tottori-u.ac.jp/records/503030a575df-b6af-4b32-8400-0b2d62dea903
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
52_095-104(1).pdf (229.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Helminth Infections Prevent Autoimmune Diseases through Th2-Type Immune Response | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | alternatively activated macrophage | |||||
| キーワード | ||||||
| 主題 | autoimmune disease | |||||
| キーワード | ||||||
| 主題 | helminth | |||||
| キーワード | ||||||
| 主題 | T helper 2 | |||||
| キーワード | ||||||
| 主題 | thymic stromal lymphopoietin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | alternatively activated macrophage | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | autoimmune disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | helminth | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | T helper 2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | thymic stromal lymphopoietin | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukumoto, Soji
× Fukumoto, Soji× Iriko, Hideyuki× Otsuki, Hitoshi |
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| 著者所属 | ||||||
| 値 | Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Molecular Parasitology, Ehime University Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Helminth parasites are known to elicit the immune response towards T helper 2 (Th2)-type, characterized by Th2 related cytokines, that typically include interleukin-4 (IL-4), IL-5 and IL-13. In this review we will describe the mechanisms involved in helminth induced Th2 immune response. Intestinal epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP), which is both necessary and sufficient for the initiation of Th2 cytokine-driven inflammation. IL-33 mRNA is expressed early during parasite infection and IL-33 binds ST2 receptor, both of which are associated with optimal CD4+ Th2 polarization. Following innate immune cell recognition, basophils and mast cell can secrete Th2 type cytokines that are thought to contribute to CD4+ Th2 differentiation. Additionaly, dendritic cell conditioned with some helminth products can promote CD4+ Th2 differentiation. Alternatively activated macrophages, activated by the Th2 cytokines IL-4 and IL-13 in parasitic infections, contribute to the host protective response: control of Th1-type inflammation, wound healing and worm expulsion. Experimentally, helminths have been associated with protection against a number of autoimmune disorders, including inflammatory bowel diseases and type 1 diabetes. It may be a novel strategy to ameliorate autoimmune inflammation by expanding and activating the Th2 response originated from parasites. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 52, 号 3, p. 95-104, 発行日 2009-09 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2009, 52(3), 95-104 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
