| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Alteration of Concanavalin A Binding Glycoproteins in Cerebrospinal Fluid and Serum of Alzheimer's Disease Patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Alzheimer’s disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
concanavalin A |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
glycoprotein |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
glycosylation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Alzheimer’s disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
concanavalin A |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glycoprotein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glycosylation |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Hashimoto, Yuki
Taniguchi, Miyako
Kitaura, Miki
Nakamura, Yuka
Jinbo, Daiki
Urakami, Katsuya
Hashimoto, Yuki
Kitaura, Miki
Nakamura, Yuka
Jinbo, Daiki
|
| 著者所属 |
|
|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Department of Biological Regulation,School of Health Science,Tottori University Faculty of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. It is characterized pathologically by the formation of senile plaques and neurofibrilly tangles in the brain. Diagnostic markers for detecting earlier stages of AD are needed. We measured the intensity of concanavalin A (Con A) binding activities of glycoproteins of the cerebrospinal fluid (CSF) and serum of subjects to clarify the modification of core mannose since we expected that aberrant glycosylation of glycoproteins might be useful as a new biomarker for detecting AD. CSF samples were collected from 15 patients with probable AD (AD group), 5 patients with probable dementia with Lewy bodies (DLB) (DLB group) and 8 controls without dementia (control group), whereas serum samples from 20 patients with probable AD and 20 controls without dementia were also collected. Glycoproteins in the CSF and serum were detected by lectin blotting using Con A. In the CSF of the AD group, 2 Con A binding glycoproteins were significantly higher compared with the control group. Furthermore, using analysis of variance, 3 Con A binding glycoproteins detected from the CSF of the AD group showed significant differences among the 3 groups. The levels of 3 Con A binding glycoproteins were significantly lower than in non-dementia controls in the serum. These changes in Con A binding activities did not depend on the amount of proteins. Therefore, the data indicate that the aberrance of protein glycosylation relates to the pathology of AD, and has some promise as a new biomarker for the diagnosis of AD. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 51,
号 1,
p. 1-9,
発行日 2008-03
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| 出版者 |
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|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
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|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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|
関連名称 |
Yonago Acta medica. 2008, 51(1), 1-9 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
51_001-009.pdf (403.4 kB)
