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This regimen was done to obtain sufficient cure rates for H. pylori infection using a high dose of LPZ (60 mg/day) without the great cost of having to determine the genotype. However, the failure rate for eradicating H. pylori was reported to be 12.5%. The reasons for this were studied in 33 Japanese patients with H. pylori-positive gastric or duodenal ulcer. Blood samples of the patients were collected to determine the genotype of CYP2C19 and plasma concentrations of LPZ and its metabolites at 3 h postdose on the morning of the 7th day of treatment. H. pylori infection was cured in 25 of the 33 patients (75.8%). The cure rate was highest in the group of poor metabolizers (PM), intermediate in the group of extensive metabolizers of the heterozygous type (htEM) and lowest in the group of extensive metabolizers of the homozygous type (hmEM). The relative ratio of mean plasma concentration for LPZ among the 3 groups was 1.00:1.43:2.93 (hmEM:htEM:PM groups). Our data suggest that success of the eradication is dependent on the CYP2C19-related genotypic status or the plasma concentrations of LPZ in a steady state condition after a multiple dosing regimen; that is to say, checking CYP2C19 is necessary even on occasions when treatment is done by H. pylori eradication methods as performed in Japan.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 2008, 51(2), 31-38"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica 編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "186"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Division of Pharmacotherapeutics,Department of Pathophysiological and Therapeutic Science,School of Medicine,Tottori University Faculty of Medicine. 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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 51
  4. 2

Effect of CYP2C19 Polymorphism on Treatment Success in Lansoprazole-Based 7-Day Treatment Regimen for Cure of H. pylori Infection in Japan

https://repository.lib.tottori-u.ac.jp/records/5039
https://repository.lib.tottori-u.ac.jp/records/5039
93d56088-5a84-4dee-8244-ee556a03bbfa
名前 / ファイル ライセンス アクション
yam51(2)_031-038.pdf yam51(2)_031-038.pdf (120.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
言語 en
タイトル Effect of CYP2C19 Polymorphism on Treatment Success in Lansoprazole-Based 7-Day Treatment Regimen for Cure of H. pylori Infection in Japan
言語
言語 eng
キーワード
主題 CYP2C19
キーワード
主題 Helicobacter pylori
キーワード
主題 Japan
キーワード
主題 lansoprazole
キーワード
言語 en
主題 CYP2C19
キーワード
言語 en
主題 Helicobacter pylori
キーワード
言語 en
主題 Japan
キーワード
言語 en
主題 lansoprazole
資源タイプ
資源タイプ journal article
著者 Kishimoto, Yosuke

× Kishimoto, Yosuke

WEKO 1562
e-Rad 10273905

Kishimoto, Yosuke

en Kishimoto, Yosuke

Search repository
Yashima, Kazuo

× Yashima, Kazuo

WEKO 4429
e-Rad 80314590
研究者総覧鳥取大学 100000443

Yashima, Kazuo

en Yashima, Kazuo

Search repository
Sano, Akiko

× Sano, Akiko

WEKO 3158
e-Rad 80335512

Sano, Akiko

en Sano, Akiko

Search repository
Koda, Masaharu

× Koda, Masaharu

WEKO 18528

Koda, Masaharu

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Mukoyama, Tomoyuki

× Mukoyama, Tomoyuki

WEKO 18529

Mukoyama, Tomoyuki

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Yanagidani, Atsushi

× Yanagidani, Atsushi

WEKO 18530

Yanagidani, Atsushi

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Udagawa, Akihide

× Udagawa, Akihide

WEKO 18531

Udagawa, Akihide

Search repository
Kawaguchi, Koichiro

× Kawaguchi, Koichiro

WEKO 1397
e-Rad 10403403
研究者総覧鳥取大学 100000350

Kawaguchi, Koichiro

en Kawaguchi, Koichiro

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Nomi, Takahiro

× Nomi, Takahiro

WEKO 18532

Nomi, Takahiro

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Kitamura, Atsushi

× Kitamura, Atsushi

WEKO 18533

Kitamura, Atsushi

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Fujii, Yasuyoshi

× Fujii, Yasuyoshi

WEKO 18534

Fujii, Yasuyoshi

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Tsutsumi, Atsushi

× Tsutsumi, Atsushi

WEKO 18535

Tsutsumi, Atsushi

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Takano, Yuji

× Takano, Yuji

WEKO 18536

Takano, Yuji

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Kitaoka, Shuji

× Kitaoka, Shuji

WEKO 18537

Kitaoka, Shuji

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Miura, Norimasa

× Miura, Norimasa

WEKO 2174
e-Rad 30325005

Miura, Norimasa

en Miura, Norimasa

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Kitano, Masayuki

× Kitano, Masayuki

WEKO 18538

Kitano, Masayuki

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Maeda, Naoto

× Maeda, Naoto

WEKO 1108
e-Rad 50193503
研究者総覧鳥取大学 100000464

Maeda, Naoto

en Maeda, Naoto

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Hosoda, Akihide

× Hosoda, Akihide

WEKO 18539

Hosoda, Akihide

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Shiota, Goshi

× Shiota, Goshi

WEKO 3368
e-Rad 70263457
研究者総覧鳥取大学 100000303

Shiota, Goshi

en Shiota, Goshi

Search repository
Murawaki, Yoshikazu

× Murawaki, Yoshikazu

WEKO 2381
e-Rad 90144659

Murawaki, Yoshikazu

en Murawaki, Yoshikazu

Search repository
Hasegawa, Junichi

× Hasegawa, Junichi

WEKO 597
e-Rad 60189529

Hasegawa, Junichi

en Hasegawa, Junichi

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Koda, Masaharu

× Koda, Masaharu

WEKO 18540

en Koda, Masaharu

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Mukoyama, Tomoyuki

× Mukoyama, Tomoyuki

WEKO 18541

en Mukoyama, Tomoyuki

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Yanagidani, Atsushi

× Yanagidani, Atsushi

WEKO 18542

en Yanagidani, Atsushi

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Udagawa, Akihide

× Udagawa, Akihide

WEKO 18543

en Udagawa, Akihide

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Nomi, Takahiro

× Nomi, Takahiro

WEKO 18544

en Nomi, Takahiro

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Kitamura, Atsushi

× Kitamura, Atsushi

WEKO 18545

en Kitamura, Atsushi

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Fujii, Yasuyoshi

× Fujii, Yasuyoshi

WEKO 18546

en Fujii, Yasuyoshi

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Tsutsumi, Atsushi

× Tsutsumi, Atsushi

WEKO 18547

en Tsutsumi, Atsushi

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Takano, Yuji

× Takano, Yuji

WEKO 18548

en Takano, Yuji

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Kitaoka, Shuji

× Kitaoka, Shuji

WEKO 18549

en Kitaoka, Shuji

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Kitano, Masayuki

× Kitano, Masayuki

WEKO 18550

en Kitano, Masayuki

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Hosoda, Akihide

× Hosoda, Akihide

WEKO 18551

en Hosoda, Akihide

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著者所属
Division of Pharmacotherapeutics,Department of Pathophysiological and Therapeutic Science,School of Medicine,Tottori University Faculty of Medicine. Department of Internal Medicine,Hitachi General Hospital.
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Pharmacotherapeutics,Department of Pathophysiological and Therapeutic Science,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Pharmacotherapeutics,Department of Pathophysiological and Therapeutic Science,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Gastroenterology and Hepatology,Department of Internal Medicine,Kinki University School of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Molecular and Genetic Medicine,Department of Genetic Medicine and Regenerative Therapeutics,Institute of Regenerative Medicine and Biofunction,Graduate School of Medical Sciences,Tottori University Faculty of Medicine
著者所属
Division of Medicine and Clinical Science,Department of Multidisciplinary Internal Medicine,School of Medicine,Tottori University Faculty of Medicine
著者所属
Division of Pharmacotherapeutics,Department of Pathophysiological and Therapeutic Science,School of Medicine,Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 Recently, Helicobacter pylori (H. pylori)-positive peptic ulcer patients were treated by a 1-week triple therapy [lansoprazole (LPZ) 30 mg, amoxicillin 750 mg and clarithromycin 200 or 400 mg, each twice daily] without the checking CYP2C19 genotype in Japan. This regimen was done to obtain sufficient cure rates for H. pylori infection using a high dose of LPZ (60 mg/day) without the great cost of having to determine the genotype. However, the failure rate for eradicating H. pylori was reported to be 12.5%. The reasons for this were studied in 33 Japanese patients with H. pylori-positive gastric or duodenal ulcer. Blood samples of the patients were collected to determine the genotype of CYP2C19 and plasma concentrations of LPZ and its metabolites at 3 h postdose on the morning of the 7th day of treatment. H. pylori infection was cured in 25 of the 33 patients (75.8%). The cure rate was highest in the group of poor metabolizers (PM), intermediate in the group of extensive metabolizers of the heterozygous type (htEM) and lowest in the group of extensive metabolizers of the homozygous type (hmEM). The relative ratio of mean plasma concentration for LPZ among the 3 groups was 1.00:1.43:2.93 (hmEM:htEM:PM groups). Our data suggest that success of the eradication is dependent on the CYP2C19-related genotypic status or the plasma concentrations of LPZ in a steady state condition after a multiple dosing regimen; that is to say, checking CYP2C19 is necessary even on occasions when treatment is done by H. pylori eradication methods as performed in Japan.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 51, 号 2, p. 31-38, 発行日 2008-06
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2008, 51(2), 31-38
著者版フラグ
出版タイプ VoR
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