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Mismatch Negativity as a Psychophysiological Index of Cognitive Function in Schizophrenia
https://repository.lib.tottori-u.ac.jp/records/5054
https://repository.lib.tottori-u.ac.jp/records/50541af25c1c-e859-415c-a686-23ec7a10eb3d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
50_023-032.pdf (214.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Mismatch Negativity as a Psychophysiological Index of Cognitive Function in Schizophrenia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | cognitive function | |||||
| キーワード | ||||||
| 主題 | functional outcome | |||||
| キーワード | ||||||
| 主題 | mismatch negativity | |||||
| キーワード | ||||||
| 主題 | N-methyl-D-aspartate | |||||
| キーワード | ||||||
| 主題 | schizophrenia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cognitive function | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | functional outcome | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mismatch negativity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | N-methyl-D-aspartate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | schizophrenia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Nakagome, Kazuyuki
× Nakagome, Kazuyuki× Ikezawa, Satoru× Pu, Sheng Hong× Nakagome, Kazuyuki× Ikezawa, Satoru |
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| 著者所属 | ||||||
| 値 | Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | It is now widely accepted that cognitive deficits, beyond other psychiatric symptoms (e.g., delusion, hallucination, emotional flattening, social withdrawal and apathy), is far most relevant to social functional outcome in schizophrenia. Accordingly, the treatment target has been shifted to the area, developing new drugs that facilitate cognitive function and building up new psychosocial rehabilitation programs that directly approach the cognitive deficits. Despite the desirability to target these deficits, no standard neuropsychological test batteries exist for assessing the level of cognitive function. Mismatch negativity (MMN), an auditory event-related potential component, is a measure of preattentive information processing and its amplitude has repeatedly been demonstrated to be reduced in schizophrenia. MMN deficits are a robust feature in chronic schizophrenia and indicate abnormalities in automatic context-dependent auditory information processing and auditory sensory memory in schizophrenia. Moreover, the deficits have been related to poor social functioning level and social skills acquisition, hypofunction of NMDA system, and illness duration, which indicate the validity of accepting MMN as a biomarker of the disease. In this article, we present a summary of the discussions about the plausibility of MMN to be used as a neurobiological index for assessing the cognitive function and also its predictability of social functional outcome in schizophrenia. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 50, 号 2, p. 23-32, 発行日 2007-06 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2007, 50(2), 23-32 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
