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Association of Functional Gene Polymorphisms of Interleukin-1β and Transforming Growth Factor-β1 with the Progression of Liver Fibrosis in Japanese Patients with Hepatitis C Virus-Related Chronic Liver Disease
https://repository.lib.tottori-u.ac.jp/records/5062
https://repository.lib.tottori-u.ac.jp/records/506240a79f09-3cba-4bc8-a184-82b854434266
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
50_089-097.pdf (216.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Association of Functional Gene Polymorphisms of Interleukin-1β and Transforming Growth Factor-β1 with the Progression of Liver Fibrosis in Japanese Patients with Hepatitis C Virus-Related Chronic Liver Disease | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | interleukin-1β | |||||
| キーワード | ||||||
| 主題 | interleukin-1 receptor antagonist | |||||
| キーワード | ||||||
| 主題 | liver fibrosis | |||||
| キーワード | ||||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 主題 | transforming growth factor-β1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | interleukin-1β | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | interleukin-1 receptor antagonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | liver fibrosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | transforming growth factor-β1 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Mandai, Mari
× Mandai, Mari× Murawaki, Yoshikazu× Okamoto, Kinya× Ohtani, Hideyuki× Maeda, Naoto× Yuasa, Isao× Mandai, Mari× Okamoto, Kinya× Ohtani, Hideyuki× Yuasa, Isao |
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| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Legal Medicine, Department of Social Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1RN) are key cytokines in an inflammatory response, and transforming growth factor β1 (TGF-β1) promotes hepatic fibrogenesis. The association of polymorphisms in the genes for these cytokines with liver fibrosis is controversial. The aim of this study was to examine the possible association of IL-1β, IL-1RN and TGF-β1 polymorphisms with the progression of liver fibrosis in the Japanese population using cross-sectional and longitudinal study designs. We examined 183 patients with hepatitis C virus (HCV)-related chronic liver disease (93 chronic hepatitis and 90 with cirrhosis). Some of the chronic hepatitis cases were divided into progressive fibrosis and non-progressive fibrosis. IL-1β ?31T/C, IL-1RN variable number of tandem repeats (VNTR) and TGF-β1 +869 T/C polymorphisms were analyzed using a polymerase-chain reaction-based assay. In the cross-sectional study, there were no significant differences in the genotype distributions of IL-1β, IL-1RN and TGF-β1 between chronic hepatitis and liver cirrhosis. No significant differences were found among Child-Pugh grades in cirrhosis patients. In the longitudinal study, there were no significant differences in the genotype distributions of IL-1β, IL-1RN and TGF-β1 between progressive fibrosis and non-progressive fibrosis. No significant differences in the speed at which liver fibrosis develop were found among the genotypes of IL-1β, IL-1RN and TGF-β1. In disagreement with other studies, the functional gene polymorphisms of IL-1β, IL-1RN and TGF-β1 were not associated with the progression of liver fibrosis in Japanese patients with HCV-related chronic liver disease. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 50, 号 4, p. 89-97, 発行日 2007-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2007, 50(4), 89-97 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
