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HRAS1 Variable Number of Tandem Repeats Polymorphism in Japanese Patients with Colorectal Adenoma and Cancer
https://repository.lib.tottori-u.ac.jp/records/5063
https://repository.lib.tottori-u.ac.jp/records/50638ac8fdd7-b98c-4804-b238-1aac624190b9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
49_001-007.pdf (111.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | HRAS1 Variable Number of Tandem Repeats Polymorphism in Japanese Patients with Colorectal Adenoma and Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | colorectal neoplasm | |||||
| キーワード | ||||||
| 主題 | HRAS1 variable number of tandem repeats | |||||
| キーワード | ||||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | colorectal neoplasm | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | HRAS1 variable number of tandem repeats | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polymorphism | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Miura, Masahiko
× Miura, Masahiko× Maeda, Naoto× Murawaki, Yoshikazu× Miura, Masahiko |
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| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The highly polymorphic HRAS1 variable number of tandem repeats (VNTR) has been described as an inherited predisposing factor in various human cancers. The aim of the present study was to evaluate the association between the presence of rare HRAS1 VNTR alleles and colorectal adenoma and cancer. A total of 165 Japanese patients underwent total colonoscopy with informed consent, and were divided into 2 groups: colorectal neoplastic and non-neoplastic patients. Two hundred and sixteen HRAS1 VNTR alleles from 108 colorectal neoplastic patients (67 adenomas and 41 cancers) and 114 alleles from 57 non-neoplastic patients were genotyped using PCR-based long-agarose gel electrophoresis assay of peripheral blood leukocyte DNA. Rare alleles were differentiated from 4 types of common allele (a1, a2, a3 and a4) by shifts in electrophoretic mobility. The prevalence of rare HRAS1 VNTR alleles was higher in colorectal neoplastic patients than in non-neoplastic patients (25.4% and 34.1% versus 8.8%). The adjusted odds ratio with at least one rare allele was 8.65 (95% confidence interval = 2.93 ? 25.53, P < 0.0001) in colorectal neoplastic patients. The presence of rare HRAS1 VNTR alleles could be a genetic predisposing factor for risk of colorectal neoplasm in Japanese people. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 1, p. 1-7, 発行日 2006-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2006, 49(1), 1-7 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
