| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
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|
タイトル |
Expression of Phospho-Akt and PTEN Proteins in Human Breast Cancer in Relation to Tumor Progression and Patient Survival |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
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主題Scheme |
Other |
|
主題 |
phosphatase and tensin homolog detected on chromosome ten |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
phosphorylated-Akt |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
prognosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phosphatase and tensin homolog detected on chromosome ten |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phosphorylated-Akt |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Yamamoto, Osamu
Gomyo, Yoshihito
Hirooka, Yasuaki
Tsujitani, Shunichi
Ikeguchi, Masahide
Yamamoto, Osamu
Gomyo, Yoshihito
Tsujitani, Shunichi
|
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 著者所属 |
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|
値 |
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Phosphatidylinositol 3-kinase (PI3-kinase) controls mitogenesis, cellular growth and transformation in a variety of cancers. The serine-threonine kinase Akt is a downstream target of PI3-kinase, and phosphorylated Akt (Phospho-Akt) inhibits apoptosis. Phosphatase and tensin homolog detected on chromosome ten (PTEN) is a tumor suppressor that antagonizes PI3-kinase activity, negatively regulates its downstream-target, Akt, inhibits phosphorylation of Akt, and medicates cell-cycle arrest and apoptosis. To clarify whether the PI3-kinase/Akt pathway and PTEN relate to breast cancer, we examined the expression of pathway-related proteins such as Phospho-Akt and PTEN in clinical specimens. Immunohistochemical analysis was performed on tissue specimens surgically obtained from 221 patients with breast cancer. The association of Phospho-Akt and PTEN expression with clinicopathological variables and the prognosis of patients were analyzed. Of 221 breast carcinomas, positive Phospho-Akt expression was observed in 91 (41.1%) and positive PTEN expression in 119 (53.8%). Phospho-Akt expression and loss of PTEN expression significantly correlated with tumor staging, tumor size and lymph node metastasis. Patients with Phospho-Akt-positive tumors had significantly inferior disease-free survival or over-all survival to those with Phospho-Akt-negative tumors, while those with PTEN positive tumors were better than those with PTEN negative tumors. Moreover, patients with Phospho-Akt-positive and PTEN-negative tumors had a significantly inferior disease-free survival and over-all survival compared to those with Phospho-Akt-negative and PTEN-positive tumors. Multivariate analysis revealed that expression of Phospho-Akt and tumor size were the independent factors (P = 0.024). We demonstrated that the expression of Phospho-Akt significantly correlated with tumor progression and patients survival with breast cancer. Phospho-Akt/PTEN expression status is possibly a definitive prognostic factor in clinical breast cancer. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 49,
号 1,
p. 19-27,
発行日 2006-03
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| 出版者 |
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出版者 |
Tottori University Faculty of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13468049 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
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|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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関連名称 |
Yonago Acta medica. 2006, 49(1), 19-27 |
| 著者版フラグ |
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出版タイプ |
VoR |
49_019-027.pdf (482.6 kB)
