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Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids
https://repository.lib.tottori-u.ac.jp/records/5067
https://repository.lib.tottori-u.ac.jp/records/506701408475-3b92-4614-8aeb-fa6a941cc74c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
49_039-047.pdf (312.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Spirometra erinaceieuropaei | |||||
| キーワード | ||||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 主題 | macrophage | |||||
| キーワード | ||||||
| 主題 | cyclooxygenase-2 | |||||
| キーワード | ||||||
| 主題 | mitogen-activated protein kinase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Spirometra erinaceieuropaei | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | macrophage | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cyclooxygenase-2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mitogen-activated protein kinase | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukumoto, Soji
× Fukumoto, Soji× Dirgahayu, Paramasari× Nunomura, Kozue× Matsuura, Haruyo× Hirai, Kazumitsu× Dirgahayu, Paramasari× Nunomura, Kozue |
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| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Present address: Department of Parasitology, Faculty of Medicine, Sebelas Maret University | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The escape mechanism of parasites from inflammatory processes has been thought to be one of the most important tools for their survival in infected tissues. On the other hand, inducible cyclooxygenase-2 (cox-2) has been shown to play a major role in the process of inflammation. We investigated the effect of excretory/secretory (ES) products from the plerocercoids of Spirometra erinaceieuropaei on cox-2 gene expression in a murine macrophage cell line (RAW 264.7). Preincubation of the macrophages with the ES products inhibited LPS-induced cox-2 mRNA expression by 75% as well as its protein production. Dibutyryl cAMP enhances LPS-induced cox-2 mRNA expression. The ES products also inhibited this enhanced expression by 46%. Inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 or that of extracellular signal-regulated protein kinase with PD98059 reduced LPS-induced cox-2 mRNA expression by 75% or 52%, respectively, along with its protein production. This evidence suggests that both MAPK pathways are crucial for full induction of cox-2 gene expression. One experiment using a transcriptional inhibitor, actinomycin-D, showed that the ES products destabilized LPS-induced cox-2 mRNA in RAW 264.7 macrophages. These results show that ES products from the plerocercoids of Spirometra erinaceieuropaei suppress LPS-induced cox-2 mRNA expression in murine RAW 264.7 macrophages, and may attenuate inflammation around the plerocercoids of S. erinaceieuropaei. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 1, p. 39-47, 発行日 2006-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2006, 49(1), 39-47 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
