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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 49
  4. 1

Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids

https://repository.lib.tottori-u.ac.jp/records/5067
https://repository.lib.tottori-u.ac.jp/records/5067
01408475-3b92-4614-8aeb-fa6a941cc74c
名前 / ファイル ライセンス アクション
49_039-047.pdf 49_039-047.pdf (312.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids
言語 en
言語
言語 eng
キーワード
主題 Spirometra erinaceieuropaei
キーワード
主題 lipopolysaccharide
キーワード
主題 macrophage
キーワード
主題 cyclooxygenase-2
キーワード
主題 mitogen-activated protein kinase
キーワード
言語 en
主題 Spirometra erinaceieuropaei
キーワード
言語 en
主題 lipopolysaccharide
キーワード
言語 en
主題 macrophage
キーワード
言語 en
主題 cyclooxygenase-2
キーワード
言語 en
主題 mitogen-activated protein kinase
資源タイプ
資源タイプ journal article
著者 Fukumoto, Soji

× Fukumoto, Soji

WEKO 423
e-Rad 60111126
研究者総覧鳥取大学 100000234

Fukumoto, Soji

en Fukumoto, Soji

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Dirgahayu, Paramasari

× Dirgahayu, Paramasari

WEKO 18708

Dirgahayu, Paramasari

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Nunomura, Kozue

× Nunomura, Kozue

WEKO 18709

Nunomura, Kozue

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Matsuura, Haruyo

× Matsuura, Haruyo

WEKO 2077
e-Rad 70243409

Matsuura, Haruyo

en Matsuura, Haruyo

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Hirai, Kazumitsu

× Hirai, Kazumitsu

WEKO 715
e-Rad 20093940

Hirai, Kazumitsu

en Hirai, Kazumitsu

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Dirgahayu, Paramasari

× Dirgahayu, Paramasari

WEKO 18710

en Dirgahayu, Paramasari

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Nunomura, Kozue

× Nunomura, Kozue

WEKO 18711

en Nunomura, Kozue

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著者所属
値 Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Present address: Department of Parasitology, Faculty of Medicine, Sebelas Maret University
著者所属
値 Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 The escape mechanism of parasites from inflammatory processes has been thought to be one of the most important tools for their survival in infected tissues. On the other hand, inducible cyclooxygenase-2 (cox-2) has been shown to play a major role in the process of inflammation. We investigated the effect of excretory/secretory (ES) products from the plerocercoids of Spirometra erinaceieuropaei on cox-2 gene expression in a murine macrophage cell line (RAW 264.7). Preincubation of the macrophages with the ES products inhibited LPS-induced cox-2 mRNA expression by 75% as well as its protein production. Dibutyryl cAMP enhances LPS-induced cox-2 mRNA expression. The ES products also inhibited this enhanced expression by 46%. Inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 or that of extracellular signal-regulated protein kinase with PD98059 reduced LPS-induced cox-2 mRNA expression by 75% or 52%, respectively, along with its protein production. This evidence suggests that both MAPK pathways are crucial for full induction of cox-2 gene expression. One experiment using a transcriptional inhibitor, actinomycin-D, showed that the ES products destabilized LPS-induced cox-2 mRNA in RAW 264.7 macrophages. These results show that ES products from the plerocercoids of Spirometra erinaceieuropaei suppress LPS-induced cox-2 mRNA expression in murine RAW 264.7 macrophages, and may attenuate inflammation around the plerocercoids of S. erinaceieuropaei.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 49, 号 1, p. 39-47, 発行日 2006-03
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2006, 49(1), 39-47
著者版フラグ
出版タイプ VoR
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