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Mallory Bodies in Hepatocytes of Alcoholic Liver Disease and Primary Biliary Cirrhosis Contain Nε-(Carboxymethyl)lysine-Modified Cytokeratin, but not those in Hepatic Carcinoma Cells
https://repository.lib.tottori-u.ac.jp/records/5073
https://repository.lib.tottori-u.ac.jp/records/507339652037-6274-45dd-bab6-b0b37bdd7342
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
49_083-092.pdf (362.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Mallory Bodies in Hepatocytes of Alcoholic Liver Disease and Primary Biliary Cirrhosis Contain Nε-(Carboxymethyl)lysine-Modified Cytokeratin, but not those in Hepatic Carcinoma Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | advanced glycation end product | |||||
| キーワード | ||||||
| 主題 | cytokeratin | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | Mallory body | |||||
| キーワード | ||||||
| 主題 | Nε-(carboxymethyl)lysine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | advanced glycation end product | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cytokeratin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Mallory body | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Nε-(carboxymethyl)lysine | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kato, Masako
× Kato, Masako× Kato, Shinsuke× Horiuchi, Seikoh× Nagai, Ryoji× Horie, Yasushi× Hayashi, Kazuhiko× Horiuchi, Seikoh× Nagai, Ryoji |
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| 著者所属 | ||||||
| 値 | Pathology Division, Tottori University Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Department of Biochemistry, Kumamoto University School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Department of Biochemistry, Kumamoto University School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Pathology Division, Tottori University Hospital | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Pathology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Mallory bodies (MBs) are intracytoplasmic bodies seen in hepatocytes of alcoholic liver disease, primary biliary cirrhosis and hepatocellular carcinoma. However, the mechanism of MB formation has not been fully understood. Proteins could be modified to advanced glycation end products (AGEs) after long-term incubation with reducing sugar. AGEs are known to accumulate in several tissues in aging and age-enhanced disorders. To study the possible glycation process in the formation of MBs, hepatocytes of 80 human liver tissues with MBs were subjected to immunohistochemical analyses with five AGEs, two markers for oxidative stress proteins (OSPs) and four stress-response proteins (SRPs). MBs in hepatocytes of primary biliary cirrhosis and alcoholic liver disease were strongly positive for Nε-(carboxymethyl)lysine (CML) and weakly positive for pyrraline. MBs in hepatocellular carcinomas were negative for both CML and pyrraline. No significant immunoreactivity was detected in MBs for other AGEs, such as Nε-(carboxyethyl)lysine, pentosidine, and 3DG-imidazolone, or for OSPs and SRPs. Stainings for cytokeratin, a major protein component of MBs, and CML were co-localized. Furthermore, immunoblot analysis suggested that cytokeratin of MBs was modified to AGE, since a single protein band detected by a monoclonal anti-CML had a molecular weight identical to cytokeratin. The absence of the CML signal in MBs of hepatocellular carcinoma cells could be explained by scarce content of cytokeratin in carcinoma MBs. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 49, 号 3, p. 83-92, 発行日 2006-09 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2006, 49(3),83-92 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
