ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 48
  4. 1

The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines

https://repository.lib.tottori-u.ac.jp/records/5076
https://repository.lib.tottori-u.ac.jp/records/5076
2a4ca1c5-a1f0-4892-8a2c-740aa941da70
名前 / ファイル ライセンス アクション
48_007-016.pdf 48_007-016.pdf (440.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines
言語 en
言語
言語 eng
キーワード
主題 apoptosis
キーワード
主題 gastric cancer
キーワード
主題 PI3K-Akt pathway
キーワード
主題 SN-38
キーワード
言語 en
主題 apoptosis
キーワード
言語 en
主題 gastric cancer
キーワード
言語 en
主題 PI3K-Akt pathway
キーワード
言語 en
主題 SN-38
資源タイプ
資源タイプ journal article
著者 Yoshioka, Shizue

× Yoshioka, Shizue

WEKO 18756

Yoshioka, Shizue

Search repository
Tatebe, Shigeru

× Tatebe, Shigeru

WEKO 18757

Tatebe, Shigeru

Search repository
Tokuyasu, Naruo

× Tokuyasu, Naruo

WEKO 3905
研究者総覧鳥取大学 100000393

Tokuyasu, Naruo

en Tokuyasu, Naruo

Search repository
Taniguchi, Kenjiro

× Taniguchi, Kenjiro

WEKO 18758

Taniguchi, Kenjiro

Search repository
Ogami, Yoshimi

× Ogami, Yoshimi

WEKO 18759

Ogami, Yoshimi

Search repository
Yamamoto, Osamu

× Yamamoto, Osamu

WEKO 18760

Yamamoto, Osamu

Search repository
Ashida, Keigo

× Ashida, Keigo

WEKO 153
e-Rad 00346355
研究者総覧鳥取大学 100000312

Ashida, Keigo

en Ashida, Keigo

Search repository
Gomyo, Yoshihito

× Gomyo, Yoshihito

WEKO 18761

Gomyo, Yoshihito

Search repository
Kondo, Akira

× Kondo, Akira

WEKO 1695
e-Rad 90304211

Kondo, Akira

en Kondo, Akira

Search repository
Tsujitani, Shunichi

× Tsujitani, Shunichi

WEKO 18762

Tsujitani, Shunichi

Search repository
Ikeguchi, Masahide

× Ikeguchi, Masahide

WEKO 905
e-Rad 20193188

Ikeguchi, Masahide

en Ikeguchi, Masahide

Search repository
Yoshioka, Shizue

× Yoshioka, Shizue

WEKO 18763

en Yoshioka, Shizue

Search repository
Tatebe, Shigeru

× Tatebe, Shigeru

WEKO 18764

en Tatebe, Shigeru

Search repository
Taniguchi, Kenjiro

× Taniguchi, Kenjiro

WEKO 18765

en Taniguchi, Kenjiro

Search repository
Ogami, Yoshimi

× Ogami, Yoshimi

WEKO 18766

en Ogami, Yoshimi

Search repository
Yamamoto, Osamu

× Yamamoto, Osamu

WEKO 18767

en Yamamoto, Osamu

Search repository
Gomyo, Yoshihito

× Gomyo, Yoshihito

WEKO 18768

en Gomyo, Yoshihito

Search repository
Tsujitani, Shunichi

× Tsujitani, Shunichi

WEKO 18769

en Tsujitani, Shunichi

Search repository
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 SN-38, an active metabolite of a topoisomerase I inhibitor, CPT-11, exhibits a cytotoxic effect by inducing apoptosis in cancer cells. Phosphatidylinositol-3-OH kinase (PI3K)-Akt signaling is known to protect a variety of cells from apoptosis. The relationship between resistance to SN-38-induced apoptosis and the PI3K-Akt pathway in human gastric cancer cells is unknown. Here, we did an investigation using two gastric cancer cell lines, MKN1 and MKN45. Cell viability was determined by sodium 3'-[1-(phenylaminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro) benzene sulfonic acid hydrate (XTT) assay. Apoptosis was confirmed by fluorescence microscopy using Hoechst 33342 staining. Expression levels of phospho-Akt (pAkt) were determined by Western blotting. After being treated with SN-38, the populations of sub-G1 cells were induced by flow cytometry in 36.8% of MKN45 cells more frequently than in 13.5% of MKN1 cells. SN-38 inhibited the expression of pAkt dose-dependently in MKN45 cells, but not in MKN1 cells. In MKN1 cells, an additional pretreatment with the PI3K inhibitor, LY294002, led to the inhibition of pAkt expression and induced apoptosis. The results suggested that SN-38 induces apoptosis by decreasing PI3K-Akt survival signaling, the anti-apoptotic signals, in human gastric cancer cells. Akt inhibitor might be a useful anti-tumor agent in combination with CPT-11.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 48, 号 1, p. 7-16, 発行日 2005-03
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2005, 48(1), 7-16
著者版フラグ
出版タイプ VoR
戻る
0
views
See details
Views

Versions

Ver.1 2023-08-02 07:08:58.757451
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3