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Effects of Metoclopramide Hydrochloride, a D2-Selective Dopamine Receptor Antagonist, on the Fast Oscillation of the Electrooculogram
https://repository.lib.tottori-u.ac.jp/records/5084
https://repository.lib.tottori-u.ac.jp/records/50849c3a477f-a0d5-4913-8440-422ccaa94b45
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
48_083-092.pdf (294.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effects of Metoclopramide Hydrochloride, a D2-Selective Dopamine Receptor Antagonist, on the Fast Oscillation of the Electrooculogram | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | D2-selective dopamine receptor antagonist | |||||
| キーワード | ||||||
| 主題 | dopamine | |||||
| キーワード | ||||||
| 主題 | electrooculogram | |||||
| キーワード | ||||||
| 主題 | fast oscillation | |||||
| キーワード | ||||||
| 主題 | metoclopramide hydrochloride | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | D2-selective dopamine receptor antagonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dopamine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | electrooculogram | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fast oscillation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | metoclopramide hydrochloride | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Miki, Norio
× Miki, Norio× Nakao, Hiroshi× Hasegawa, Jiro× Baba, Takashi× Ishikura, Ryoko× Kakimaru, Akiko× Sakatani, Keiko× Yamasaki, Atsushi× Sasaki, Yuji× Tamai, Akihiko× Miki, Norio× Nakao, Hiroshi× Hasegawa, Jiro× Ishikura, Ryoko× Kakimaru, Akiko× Sakatani, Keiko |
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| 著者所属 | ||||||
| 値 | Clinic of Ophthalmology, Miki Eye Clinic | |||||
| 著者所属 | ||||||
| 値 | Clinic of Ophthalmology, Nakao Eye Clinic | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Clinic of Ophthalmology, Hino Hospital Association Hino Hospital | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Fast oscillation (FO) of an electrooculogram (EOG) was recorded in both eyes of 10 healthy volunteers before and after administration of metoclopramide hydrochloride (MTCL), a D2-selective dopamine receptor antagonist, paying particular attention to sex concerning sensitivity to dopamine in young subjects. Healthy volunteers were divided into male and female groups; 5 males (10 eyes) aged 21 to 23 years (average, 21.8 years) and 5 females (10 eyes) aged 19 to 25 years (average, 21.8 years). As an FO parameter, the dfFO (the averaged difference in ?V between maximum amplitude in the dark period and minimum amplitude in the light period during FO measurement) was evaluated. The mean level of dfFO significantly increased between phase A (the initial 10 min before intravenous injection of 10 mg of MTCL) and phase B (10 min after the injection) in the male and female groups (P < 0.01 and P < 0.025) and between phase A and phase C (the additional 10 min after the injection) in both groups (P < 0.01 and P < 0.05). The mean level of dfFO in the female group was significantly higher than that of the male group in phase B (P < 0.05). As a control, the experimental procedure was performed with physiological saline administration, and no changes were observed. The data suggest that there exists some difference between young males and females generation concerning sensitivity to dopamine and that young females may show a higher-than-male sensitivity to dopamine in the occurrence of FO potential. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 48, 号 4, p. 83-92, 発行日 2005-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2005, 48(4), 83-92 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
