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An Immunohistochemical Study of Perivascular Plaque in Alzheimer’s Disease and Cerebral Amyloid Angiopathy
https://repository.lib.tottori-u.ac.jp/records/5099
https://repository.lib.tottori-u.ac.jp/records/5099e756ed95-1b37-44a4-a73a-6f5bfa1c47c1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_009-016.pdf (342.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | An Immunohistochemical Study of Perivascular Plaque in Alzheimer’s Disease and Cerebral Amyloid Angiopathy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Alzheimer's disease | |||||
| キーワード | ||||||
| 主題 | cerebral amyloid angiopathy | |||||
| キーワード | ||||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題 | perivascular plaque | |||||
| キーワード | ||||||
| 主題 | senile plaque | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Alzheimer's disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cerebral amyloid angiopathy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | perivascular plaque | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | senile plaque | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yang, Chun-Hui
× Yang, Chun-Hui× Otsuka, Makoto× Ohama, Eisaku× Yang, Chun-Hui× Otsuka, Makoto× Ohama, Eisaku |
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| 著者所属 | ||||||
| 値 | Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Immunohistochemical study of perivascular plaques (PPs) in 7 patients with Alzheimer’s disease (AD) and 4 with cerebral amyloid angiopathy (CAA)(CAA with dementia in 3 patients and CAA with massive cerebral hemorrhage in 1 patient) demonstrated that PPs were also a common form of amyloid β (Aβ) deposits, like SPs and CAAs, in both AD and CAA, and that they had similar immunostaining characteristics to mature senile plaques (SPs), manifesting as always positive for both Aβ42 and Aβ40 but predominant for Aβ42. In addition, PPs were always associated with AT8-positive degenerated neurites and GFAP-positive astrocytes and fibers. These findings suggest that PPs as mature plaques contribute to the development of dementia, especially in CAA with dementia which lack AD pathology. Moreover, semiquantitative analysis revealed no correlation between the number of PPs and that of SPs, but a good correlation between the number of PPs and that of CAAs, suggesting that there was a close relationship of the formation of PPs and the development of CAAs. PPs were also found around non-CAA arteries, although they were frequent around varying degrees of CAAs, suggesting that the initial Aβ42 deposits in PPs contribute to the development of CAAs. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 1, p. 9-16, 発行日 2003-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2003, 46(1), 9-16 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
