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Angiotensin II and Fever in Rodents
https://repository.lib.tottori-u.ac.jp/records/5109
https://repository.lib.tottori-u.ac.jp/records/51099f47077b-79d0-4186-be45-6961bf7ebc57
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_083-090.pdf (113.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Angiotensin II and Fever in Rodents | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | AT1 receptor | |||||
| キーワード | ||||||
| 主題 | AT2 receptor | |||||
| キーワード | ||||||
| 主題 | interleukin-1 | |||||
| キーワード | ||||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 主題 | prostaglandin E2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | AT1 receptor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | AT2 receptor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | interleukin-1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | prostaglandin E2 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Watanabe, Tatsuo
× Watanabe, Tatsuo× Miyoshi, Michio× Imoto, Toshiaki |
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| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Angiotensin II (ANG II), a bioactive peptide well known to play an important role in blood-pressure and body-fluid regulation, participates in inflammatory responses, too. Recently, we reported results suggesting that ANG II is involved in the development of the fever induced by intravenous (i.v.) injection of lipopolysaccharide (LPS, 2 ?g/kg) in dehydrated rats (in which the secretion of ANG II is elevated). Furthermore, we verified the contributions made by ANG II and its type 1 receptor (AT1 receptor) to the LPS-induced production of interleukin-1β ; (IL-1β) in those rats. It therefore seems likely that in rats, ANG II and its receptors contribute to the induction of this fever at its 1st step (namely, the LPS-induced production of pyrogenic cytokines such as IL-1β). Moreover, we have revealed that intrahypothalamic (i.h.) ANG II and AT2 receptors are involved in the development of the fever induced by i.h. injection of prostaglandin E2 (PGE2), a final fever mediator. ANG II given i.h., which had no effect on the resting body temperature, facilitated PGE2-induced fever. These results suggest that in rats, ANG II and its receptors contribute to the induction of fever at its final step, too (namely, the action of PGE2 to cause fever). Finally, a single i.p. injection of IL-1β results in a weaker IL-1β-induced fever in AT2-receptor-deficient mice than in wild-type mice, suggesting that the brain AT2 receptor is involved in the development of fever (possibly at its final step) in mice as well. Collectively, these results suggest that in rodents, ANG II and its receptors contribute to the development of fever, both at the 1st and final steps in the pathway for fever induction. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 4, p. 83-90, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2003, 46(4), 83-90 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
