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Induction of Hepatocyte Nuclear Factor 3γ Gene Expression by the Extracellular Matrix Component from Fish Skin
https://repository.lib.tottori-u.ac.jp/records/5111
https://repository.lib.tottori-u.ac.jp/records/5111bd5a3ba0-3cdd-4072-83c6-4c5029bcfed8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_103-108.pdf (52.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Induction of Hepatocyte Nuclear Factor 3γ Gene Expression by the Extracellular Matrix Component from Fish Skin | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | dermatan sulfate | |||||
| キーワード | ||||||
| 主題 | fish skin | |||||
| キーワード | ||||||
| 主題 | human hepatoma cell 3γ | |||||
| キーワード | ||||||
| 主題 | liver function | |||||
| キーワード | ||||||
| 主題 | reporter assay | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | dermatan sulfate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | fish skin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | human hepatoma cell 3γ | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | liver function | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | reporter assay | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Noguchi, Makoto
× Noguchi, Makoto× Takahashi, Yusuke× Taniguchi, Makoto× Isa, Shun-ichi× Arifuku, Ichiro× Yamashita, Akimichi× Sato, Kenzo× Noguchi, Makoto× Takahashi, Yusuke× Taniguchi, Makoto× Isa, Shun-ichi× Arifuku, Ichiro× Yamashita, Akimichi |
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| 著者所属 | ||||||
| 値 | Industrial Research Institute of Tottori Prefecture | |||||
| 著者所属 | ||||||
| 値 | Industrial Research Institute of Tottori Prefecture, Division of Molecular Biology, Department of Molecular and Cellular Biology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Biology, Department of Molecular and Cellular Biology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Biology, Department of Molecular and Cellular Biology, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Industrial Research Institute of Tottori Prefecture | |||||
| 著者所属 | ||||||
| 値 | Industrial Research Institute of Tottori Prefecture | |||||
| 著者所属 | ||||||
| 値 | Division of Molecular Biology, Department of Molecular and Cellular Biology, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The skin of the halibut (Reinhararditus hippoglossoides) has long been discarded as a waste product by the food industry in large quantities; hence, we examined the biological activity in the skin for utilization of the waste. In the present study, we determined induction of hepatocyte nuclear factor 3γ (HNF3γ), which is involved in liver function, using human hepatoma cell line HepG2 and extracellular matrix components extracted from the fish skin. Induction of the HNF3γ was detected by reporter plasmid constructed with the promoter region of the HNF3γ gene and luciferase or green fluorescent protein genes. The alkali extract containing proteoglycan showed HNF3γ induction, but the acid-extract enriched in collagen did not. Consequently, dermatan sulfate showed the strongest activity in HNF3γ induction. These observations suggested that fish skin has some significant biological activity, and indicates its possible function in the food and drug industry. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 4, p. 103-108, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2003, 46(4), 103-108 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
