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Mismatch Repair Deficiency in Patients with Double Primary Cancer of the Colorectum and Stomach
https://repository.lib.tottori-u.ac.jp/records/5113
https://repository.lib.tottori-u.ac.jp/records/511377a47803-fb5a-46a3-bf4f-a4c01719e61d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_117-124.pdf (341.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Mismatch Repair Deficiency in Patients with Double Primary Cancer of the Colorectum and Stomach | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | colorectum | |||||
| キーワード | ||||||
| 主題 | double primary cancer | |||||
| キーワード | ||||||
| 主題 | mismatch repair deficiency | |||||
| キーワード | ||||||
| 主題 | stomach | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | colorectum | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | double primary cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mismatch repair deficiency | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | stomach | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Takemoto, Hiroki
× Takemoto, Hiroki× Makino, Masato× Takemoto, Hiroki× Makino, Masato |
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| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We examined the correlation between the expression of mismatch repair (MMR) gene proteins and the development of double primary cancer, and studied clinical implications of an MMR deficiency in 15 patients with double primary cancer of the colorectum and stomach, immunohistochemically. The results were compared between the double primary cancer group of 15 patients and the control group consisting of 155 colorectal cancer (CRC) patients who had never developed other malignant diseases. Patients with hereditary nonpolyposis colorectal cancer and familial adenomatous polyiposis were excluded from both groups. The MMR deficiency in CRC was significantly more frequently detected in the double primary cancer group than in the control group (46.7% versus 20.6%, P < 0.05). Patients with MMR-deficient CRC of the double primary cancer group were significantly older, more frequently had poorly differentiated lesions, had less metastases to the liver and lymph node, and were more advanced in depth of invasion than those of the control group. We concluded that MMR deficiency might correlate with the development of double primary cancer of the colorectum and stomach. Patients with MMR-deficient CRC need periodical and intensive follow-up against the development of double primary cancer. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 46, 号 4, p. 117-124, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2003, 46(4), 117-124 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
