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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 46
  4. 4

Mismatch Repair Deficiency in Patients with Double Primary Cancer of the Colorectum and Stomach

https://repository.lib.tottori-u.ac.jp/records/5113
https://repository.lib.tottori-u.ac.jp/records/5113
77a47803-fb5a-46a3-bf4f-a4c01719e61d
名前 / ファイル ライセンス アクション
46_117-124.pdf 46_117-124.pdf (341.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Mismatch Repair Deficiency in Patients with Double Primary Cancer of the Colorectum and Stomach
言語 en
言語
言語 eng
キーワード
主題 colorectum
キーワード
主題 double primary cancer
キーワード
主題 mismatch repair deficiency
キーワード
主題 stomach
キーワード
言語 en
主題 colorectum
キーワード
言語 en
主題 double primary cancer
キーワード
言語 en
主題 mismatch repair deficiency
キーワード
言語 en
主題 stomach
資源タイプ
資源タイプ journal article
著者 Takemoto, Hiroki

× Takemoto, Hiroki

WEKO 18958

Takemoto, Hiroki

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Makino, Masato

× Makino, Masato

WEKO 18959

Makino, Masato

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Takemoto, Hiroki

× Takemoto, Hiroki

WEKO 18960

en Takemoto, Hiroki

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Makino, Masato

× Makino, Masato

WEKO 18961

en Makino, Masato

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著者所属
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
著者所属
値 Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 We examined the correlation between the expression of mismatch repair (MMR) gene proteins and the development of double primary cancer, and studied clinical implications of an MMR deficiency in 15 patients with double primary cancer of the colorectum and stomach, immunohistochemically. The results were compared between the double primary cancer group of 15 patients and the control group consisting of 155 colorectal cancer (CRC) patients who had never developed other malignant diseases. Patients with hereditary nonpolyposis colorectal cancer and familial adenomatous polyiposis were excluded from both groups. The MMR deficiency in CRC was significantly more frequently detected in the double primary cancer group than in the control group (46.7% versus 20.6%, P < 0.05). Patients with MMR-deficient CRC of the double primary cancer group were significantly older, more frequently had poorly differentiated lesions, had less metastases to the liver and lymph node, and were more advanced in depth of invasion than those of the control group. We concluded that MMR deficiency might correlate with the development of double primary cancer of the colorectum and stomach. Patients with MMR-deficient CRC need periodical and intensive follow-up against the development of double primary cancer.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 46, 号 4, p. 117-124, 発行日 2003-12
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2003, 46(4), 117-124
著者版フラグ
出版タイプ VoR
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