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Effects of Nitric Oxide on Bladder Outlet Obstruction in Rats
https://repository.lib.tottori-u.ac.jp/records/5118
https://repository.lib.tottori-u.ac.jp/records/5118484e3161-8ce4-4267-870f-f1c04e69c309
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
45_019-026.pdf (133.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Effects of Nitric Oxide on Bladder Outlet Obstruction in Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | bladder outlet obstruction | |||||
| キーワード | ||||||
| 主題 | nitric oxide | |||||
| キーワード | ||||||
| 主題 | nitric oxide synthase activity | |||||
| キーワード | ||||||
| 主題 | L-arginine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | bladder outlet obstruction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nitric oxide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | nitric oxide synthase activity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | L-arginine | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yanagi, Koji
× Yanagi, Koji× Yanagi, Koji |
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| 著者所属 | ||||||
| 値 | Department of Urology, Tottori University, Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We investigated the changes in bladder function resulting from bladder outlet obstruction (BOO), with particular emphasis on the role of nitric oide (NO) in bladder response. Twelve-week-old female Wistar rats (n = 36) were surgically treated in various ways by dividing them into 6 groups each with 6 animals: 2 sham-operated groups, 2 obstructed groups for 1 week or 6 weeks, and 2 groups obstructed and intraperitoneally injected with 150-mg/kg L-arginine once daily for 1 week or 6 weeks. We conducted bladder strip stimulation studies using carbachol and KCl. Then the bladder was used for measurement of NO synthase (NOS) activity and was also studied histologically using immunohistochemical staining. Bladders in the obstructed groups were significantly heavier than in the sham-operated groups. The mean weight of bladders in the groups obstructed and treated with L-arginine was almost the same as that in the sham-operated groups. Tissue bath studies demonstrated decreased contractility in response to cholinergic stimulation at obstruction, but contractility at obstruction was improved by L-arginine for 1 week or 6 weeks. NOS activity in bladder tissue was lower in the obstructed groups than in the sham groups, and higher in the L-arginine-combined groups than in the obstructed groups. These results indicate that bladder dysfunction may be improved by treatment with L-arginine. This study suggests that increased NO by treatment with L-arginine plays a role in improving bladder dysfunction caused by BOO. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 45, 号 1, p. 19-26, 発行日 2002-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2002, 45(1), 19-26 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
