| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
α-Naphthylisothiocyanate (ANIT) Induced Cholestasis in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
bile secretion |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
biliary lipids |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
fecal bile acids and sterols |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
α-naphthylisothiocyanate |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
serum lipids |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
urinary bile acids |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bile secretion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
biliary lipids |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fecal bile acids and sterols |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
α-naphthylisothiocyanate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serum lipids |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
urinary bile acids |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Uchida, Kiyohisa
Ogura, Yoshio
Yamaga, Nobuo
Yamada, Kazuo
Uchida, Kiyohisa
Ogura, Yoshio
Yamaga, Nobuo
Yamada, Kazuo
|
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University, and The Cell Science Research Foundation |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University |
| 著者所属 |
|
|
値 |
Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University |
| 抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
In order to distinguish the disorder of bile acid and cholesterol metabolism in α-naphthylisothiocyanate (ANIT)-induced cholestasis, we examined changes in bile acid levels and compositions in bile, serum, feces and urine, as well as cholesterol levels in bile, serum, liver and feces in Wistar male rats (10-13 weeks) after a single oral administration of 100 mg/kg of ANIT. The bile flow and the biliary secretions of cholesterol, phospholipids and bile acids markedly decreased on days 1 and 2 but increased over the normal values on day 4 and then returned to the normal ranges. The fecal excretion of bile acids decreased after the treatment and remained low by day 4 but markedly increased thereafter. The urinary excretion of bile acids changed almost in parallel with serum bile acid level, increasing to 37 mg/day on day 2, 28 mg/day on days 3-4 but to a trace on days 5-6. The urinary bile acids on day 2 mainly consisted of cholic acid while those on days 3-4 and biliary bile acids on day 4 were mostly β-muricholic acid. The serum cholesterol level markedly increased maximally on day 2 and decreased thereafter. The fecal excretion of sterols, cholesterol and coprostanol, decreased on days 1-2 but rather increased thereafter. These data suggest that the cholestasis induced by ANIT is very similar to that in bile duct ligated rats for a short period but not to those ligated for long periods. In addition, the present data suggest that the bile acid independent bile flow is impaired and the daily synthesis of bile acids, especially β-muricholic acid, is increased in the ANIT induced cholestasis. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 45,
号 2,
p. 59-68,
発行日 2002-06
|
| 出版者 |
|
|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
|
|
|
関連名称 |
Yonago Acta medica. 2002, 45(2), 59-68 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
45_059-068.pdf (303.8 kB)
