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Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor-Mediated Actions
https://repository.lib.tottori-u.ac.jp/records/5131
https://repository.lib.tottori-u.ac.jp/records/51313795241d-52dd-4a63-a83a-7e671dc7fcdb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_001-006.pdf (42.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor-Mediated Actions | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | endocrine disruptors | |||||
| キーワード | ||||||
| 主題 | receptor-mediated actions | |||||
| キーワード | ||||||
| 主題 | steroid hormones | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | endocrine disruptors | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | receptor-mediated actions | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | steroid hormones | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Indarto, Dono
× Indarto, Dono× Izawa, Masao× Indarto, Dono× Izawa, Masao |
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| 著者所属 | ||||||
| 値 | Department of Biosignaling, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Biosignaling, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors, while their non-genomic actions depend on receptors localized to the cell membrane. Recently, a number of environmental chemicals, which are now termed as endocrine disruptors, have been identified, and their unwanted effects on our lives have become serious problems all over the world. Their adverse effects on endocrine systems in animals, mostly estrogenic or anti-estrogenic, have resulted in reproductive malfunction and developmental disorders. Although aryl hydrocarbons exhibit estrogenic or anti-estrogenic activity through specific interaction with aryl hydrocarbon receptors, other chemicals seem to interact directly with estrogen receptors, α and β forms. In this paper, we surveyed the most recent understanding of endocrine disruptors from the viewpoint of steroid receptor systems. We suggest two potential mechanisms of action for endocrine disruptors. Endocrine distruptors i) directly associate with steroid receptor systems and/or ii) associate with the growth factor or the neurotransmitter receptor systems, and then upregulate the mitogen-activated protein kinase signaling cascades, leading to the ligand-independent activation of steroid receptor systems. Using these steroid receptor-dependent mechanisms, it appears that endocrine disruptors disorder our endocrine systems. We have proposed future suggestions to further understand endocrine disruptors from the viewpoint of steroid receptor systems. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 1, p. 1-6, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(1), 1-6 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
