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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 44
  4. 1

The Effect of Aging and Exogenous Testosterone Replacement on Nitric Oxide Concentration and Activity of Nitric Oxide Synthase in the Rat Corpus Cavernosum

https://repository.lib.tottori-u.ac.jp/records/5136
https://repository.lib.tottori-u.ac.jp/records/5136
d6ce8b4d-d6f9-4a56-a1a4-0371532136e6
名前 / ファイル ライセンス アクション
44_045-053.pdf 44_045-053.pdf (311.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル The Effect of Aging and Exogenous Testosterone Replacement on Nitric Oxide Concentration and Activity of Nitric Oxide Synthase in the Rat Corpus Cavernosum
言語 en
言語
言語 eng
キーワード
主題 aging
キーワード
主題 immunohistochemical staining
キーワード
主題 nitric oxide
キーワード
主題 testosterone replacement
キーワード
言語 en
主題 aging
キーワード
言語 en
主題 immunohistochemical staining
キーワード
言語 en
主題 nitric oxide
キーワード
言語 en
主題 testosterone replacement
資源タイプ
資源タイプ journal article
著者 Shiono, Manabu

× Shiono, Manabu

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Shiono, Manabu

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Shiono, Manabu

× Shiono, Manabu

WEKO 19051

en Shiono, Manabu

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著者所属
値 Department of Urology, Tottori University Faculty of Medicine
抄録
内容記述タイプ Other
内容記述 The effects of testosterone replacement on the nitric oxide (NO) concentration and activity of NO synthase (NOS) in the penis were investigated. Male Wistar rats (n = 39) were divided into 5 groups: 14-week-old males, 13-month-old males, 15-month-old males, 15-month-old males treated with low-dose testosterone replacement and 15-month-old males treated with high-dose testosterone replacement. The testosterone concentration in serum and the NO concentration in penile tissue were measured, and the endothelial NOS (eNOS) and neuronal NOS (nNOS) expressions were examined immunohistochemically. The testosterone concentration in serum tended to decrease with aging, but the 15-month-old testosterone-replaced rats maintained almost the same level as the 14-week-old rats. Nitrite and nitrite/nitrate concentrations in penile tissue tended to decrease with aging. Nitrite concentrations in the 15-month-old rats were significantly higher in the testosterone-replaced groups than in the non-replaced group, but no significant difference in nitrite/nitrate concentration was recognized between the 15-month-old rats not treated and treated with testosterone replacement. Immunohistochemical staining for eNOS and nNOS demonstrated a decreasing expression of the 2 NOSs with aging and recovering of the NOSs by testosterone replacement. The results of this study suggest that NO plays a major role in the mediation of penile erection, and testosterone replacement may favorably alter age-related erectile dysfunction.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 44, 号 1, p. 45-53, 発行日 2001-03
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2001, 44(1), 45-53
著者版フラグ
出版タイプ VoR
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