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Association of the Trp64Arg Mutation of the β3-Adrenergic Receptor with Diabetes Mellitus, Impaired Glucose Tolerance and Lifestyle in Japanese Workers
https://repository.lib.tottori-u.ac.jp/records/5137
https://repository.lib.tottori-u.ac.jp/records/51374f7d5b79-c008-4cc2-b5a8-f669e94281b8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_055-059.pdf (44.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Association of the Trp64Arg Mutation of the β3-Adrenergic Receptor with Diabetes Mellitus, Impaired Glucose Tolerance and Lifestyle in Japanese Workers | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | β3-Adrenergic receptor | |||||
| キーワード | ||||||
| 主題 | impaired glucose tolerance | |||||
| キーワード | ||||||
| 主題 | multiple risk factors | |||||
| キーワード | ||||||
| 主題 | non-insulin-dependent diabetes mellitus | |||||
| キーワード | ||||||
| 主題 | Trp64Arg polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | β3-Adrenergic receptor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | impaired glucose tolerance | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | multiple risk factors | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | non-insulin-dependent diabetes mellitus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | Trp64Arg polymorphism | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Okada, Hirofumi
× Okada, Hirofumi× Suyama, Akihiko× Osaki, Yoneatsu× Okamoto, Mikizo× Yamamoto, Toshiyuki× Nanba, Eiji× Kishimoto, Takuji× Okada, Hirofumi× Yamamoto, Toshiyuki |
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| 著者所属 | ||||||
| 値 | Second Department of Internal Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Gene Research Center, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Gene Research Center, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In order to investigate whether the Trp64Arg (a missense mutation of tryptophan for arginine at position 64 codon) polymorphism of the β3-adrenergic receptor (β3-AR) gene is related to the incidence of non-insulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT), a retrospective cohort study among Japanese workers was conducted. The subjects were Japanese workers at an occupational site in Shimane Prefecture. Informed consent was obtained from 492 workers. The baseline data were obtained at the regular health examination in 1992 and a retrospective cohort study was performed for analyzing the incidence of NIDDM and IGT in 1998. The Trp64Arg polymorphism β3-AR gene for each worker was detected by the single strand conformation polymerase analysis. Relative risks were calculated by the logistic regression analysis. The rates of Trp64Trp (TT), Trp64Arg (TA) and Arg64Arg (AA) genotypes were 66.3%, 31.1% and 2.6%, respectively. The relative risk of (TA + AA) against TT for the incidence of NIDDM and IGT by univariate analysis was 1.37 (95% incidence of NIDDM and IGT adjusted for confounders in a multiple logistic regression model including age, gender, family history, body mass index, alcohol consumption, eating habits and exercise was 1.31 (95% confidence interval, 0.65-2.67). The present findings suggested that a weak association between Trp64Arg polymorphism of the β3-AR gene and the incidence of NIDDM and IGT. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 1, p. 55-59, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(1), 55-59 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
