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A Molecular Variant of the Angiotensinogen Gene and Hypertension in a Case-Control Study in Japanese
https://repository.lib.tottori-u.ac.jp/records/5140
https://repository.lib.tottori-u.ac.jp/records/51406e9e8f78-2d5b-4783-8abb-db7da1ca1603
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_079-083.pdf (37.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | A Molecular Variant of the Angiotensinogen Gene and Hypertension in a Case-Control Study in Japanese | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | angiotensinogen | |||||
| キーワード | ||||||
| 主題 | case-control study | |||||
| キーワード | ||||||
| 主題 | genotype | |||||
| キーワード | ||||||
| 主題 | hypertension | |||||
| キーワード | ||||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | angiotensinogen | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | case-control study | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | genotype | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | hypertension | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | polymorphism | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kishimoto, Takuji
× Kishimoto, Takuji× Suyama, Akihiko× Osaki, Yoneatsu× Miyamoto, Tetsuya× Igarashi, Atsusi× Okamoto, Mikizoh× Kurosawa, Yoichi× Fukumoto, Soji× Miyamoto, Tetsuya× Igarashi, Atsusi |
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| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Hygiene, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Public Health, Tottori University Faculty of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Parasitology, Tottori University Faculty of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In order to examine the distribution of M235T (the substitution of threonine for 0methionine at position 235 codon) polymorphism genotypes of the angiotensinogen (AGT) gene and the relationship between M235T polymorphism of the AGT gene and hypertension, a descriptive study and a case-control study were performed among Japanese workers. The subjects were 2042 workers at an occupational site in Shimane Prefecture in Japan. The database was set up for the workers' regular health examination in 1998. The M235T polymorphism of the AGT gene for each worker was defined by the mutant allele specific amplification (MASA) method. The rates of M235M (MM), M235T (MT) and T235T (TT) genotypes were 3.9%, 30.7% and 65.5%, respectively. The odds ratios of MT and TT against MM for hypertension by univariate analysis were 0.77 [95% confidence interval (CI) 0.27-2.18] and 0.77 (95% CI 0.28-2.14), respectively. The odds ratios of MT and TT against MM for hypertension, adjusted for body mass index, fasting blood sugar, drinking habits, cigarette smoking and exercise in a logistic regression model, were 0.90 (95% CI 0.29-2.74) and 0.87 (95% CI 0.30-2.58), respectively. The data from this study suggests that there may be no relationship between the M235T polymorphism of the AGT gene and hypertension. Further prospective studies are needed to resolve this issue. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 44, 号 1, p. 79-83, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 2001, 44(1), 79-83 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
