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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 43
  4. 3

Effects of Testosterone on Cell Proliferation and Apoptosis in BBN-Induced Mouse Urinary Bladder Carcinogenesis

https://repository.lib.tottori-u.ac.jp/records/5164
https://repository.lib.tottori-u.ac.jp/records/5164
8b32f5dd-b79a-4e80-b285-3e43d3659a16
名前 / ファイル ライセンス アクション
43_121-130.pdf 43_121-130.pdf (315.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
言語 en
タイトル Effects of Testosterone on Cell Proliferation and Apoptosis in BBN-Induced Mouse Urinary Bladder Carcinogenesis
言語
言語 eng
キーワード
主題 apoptosis
キーワード
主題 BBN-induced mouse urinary bladder carcinogenesis
キーワード
主題 cell proliferation
キーワード
主題 testosterone
キーワード
言語 en
主題 apoptosis
キーワード
言語 en
主題 BBN-induced mouse urinary bladder carcinogenesis
キーワード
言語 en
主題 cell proliferation
キーワード
言語 en
主題 testosterone
資源タイプ
資源タイプ journal article
著者 Ohno, Hirofumi

× Ohno, Hirofumi

WEKO 19186

Ohno, Hirofumi

Search repository
Ohno, Hirofumi

× Ohno, Hirofumi

WEKO 19187

en Ohno, Hirofumi

Search repository
著者所属
Department of Urology, Faculty of Medicine, Tottori University
抄録
内容記述タイプ Other
内容記述 Human bladder cancer is nearly 3 times more common in men than in women. In general, the sex difference in incidence of human bladder carcinoma is considered to be due to industrial and environmental carcinogens or other factors, though there is no clear evidence supporting this. We suspected that the sex difference in incidence of bladder carcinoma might be due to the effects of testosterone. We investigated the effects of testosterone on mouse bladder arcinogenesis by using immunohistochemical staining and terminal-deoxynucleotidyl-transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL). A total of 94 four-week-old male mice were divided into 3 groups. In Group I, castration was carried out, then 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was administered until the end of the experiment. In Group II, 0.05% BBN was administered similarly, without castration. In Group III, 0.05% BBN was administered similarly, without castration, and 3 mg/kg of testosterone was injected intramuscularly weekly from the beginning of the experiment. All mice were cystectomized at the end of the experimental period to investigate the incidence of bladder cancer, and immunohistochemical staining and TUNEL were performed to examine the correlation between cell proliferation and apoptosis. Among the 3 groups, occurrence of bladder tumor was most frequent in Group III, and tumor induction time was the shortest. The proliferation index for tumors significantly increased as the stage and grade progressed. On the other hand, the apoptotic index for tumors significantly decreased. The proliferation index was the highest in Group III and the lowest in Group I. A significant difference in the proliferation index was observed among the 3 groups. No significant difference was observed in the apoptotic index among the 3 groups. Our results indicate that the effect of testosterone on mouse bladder carcinogenesis is more significantly related to cell proliferation than to suppression of apoptosis, with the result that testosterone promotes the occurrence of BBN-induced mouse bladder carcinomas.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 43, 号 3, p. 121-130, 発行日 2000-11
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2000, 43(3), 121-130
著者版フラグ
出版タイプ VoR
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