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  1. 学部学科区分一覧
  2. 医学部・医学系研究科・医学部附属病院
  1. 資料タイプ一覧
  2. 学術雑誌論文
  1. 鳥取大学の刊行物
  2. Yonago Acta Medica
  3. 43
  4. 3

Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis

https://repository.lib.tottori-u.ac.jp/records/5165
https://repository.lib.tottori-u.ac.jp/records/5165
209033db-4f0d-4b25-bd4b-82a9b4c7f55a
名前 / ファイル ライセンス アクション
43_131-140.pdf 43_131-140.pdf (716.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-22
タイトル
タイトル Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis
言語 en
言語
言語 eng
キーワード
主題 guinea pig
キーワード
主題 insulin-like growth factor 1
キーワード
主題 osteoarthritis
キーワード
主題 osteophyte formation
キーワード
言語 en
主題 guinea pig
キーワード
言語 en
主題 insulin-like growth factor 1
キーワード
言語 en
主題 osteoarthritis
キーワード
言語 en
主題 osteophyte formation
資源タイプ
資源タイプ journal article
著者 Ono, Masanori

× Ono, Masanori

WEKO 19188

Ono, Masanori

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Yamashita, Yasutsugu

× Yamashita, Yasutsugu

WEKO 19189

Yamashita, Yasutsugu

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Minamizaki, Takeshi

× Minamizaki, Takeshi

WEKO 19190

Minamizaki, Takeshi

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Morio, Yasuo

× Morio, Yasuo

WEKO 2282
e-Rad 50220041

Morio, Yasuo

en Morio, Yasuo

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Ono, Masanori

× Ono, Masanori

WEKO 19191

en Ono, Masanori

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Yamashita, Yasutsugu

× Yamashita, Yasutsugu

WEKO 19192

en Yamashita, Yasutsugu

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Minamizaki, Takeshi

× Minamizaki, Takeshi

WEKO 19193

en Minamizaki, Takeshi

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著者所属
値 Department of Orthopedic Surgery, Faculty of Medicine, Tottori University
著者所属
値 Department of Orthopedic Surgery, Faculty of Medicine, Tottori University
著者所属
値 Department of Orthopedic Surgery, Faculty of Medicine, Tottori University
著者所属
値 Department of Orthopedic Surgery, Faculty of Medicine, Tottori University
抄録
内容記述タイプ Other
内容記述 In this study, we investigated osteophyte formation processes in guinea pigs with spontaneous osteoarthritis, histochemically and immunohistochemically. Serial thin frontal sections of right knee joints were prepared from Hartley guinea pigs aged 1, 3, 5, 8, 12 and 18 months. The severity of osteoarthritis was evaluated by safranin-O staining, and the animals were classified into 3 groups: mild, moderate and severe. In addition, immunostaining was performed by using primary antibodies against the proliferating cell nuclear antigen (PCNA), type-I, -II and -III collagens, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor. In the mild group, there was fibrous connective tissue continuous with the synovial membrane and covering the margins of the articular cartilage of the medial tibial condyle. This tissue contained spindle-shaped fibroblastic-like cells. These cells were positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the moderate group, the chondrocytes beneath the fibroblastic-like cell layer had proliferated and were clustered together. These chondrocytes were also positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the severe group, this marginal area had been replaced by type-II collagen-positive chondrophytes, which further changed to osteophytes due to the process of endochondral ossification. In guinea pigs, fibroblastic-like cells at the margins of the articular cartilage of the knee joints seemed to be totipotent immature mesenchymal cells. These cells may be the precursors of osteophytes, and IGF-1 appears to be involved in their formation.
書誌情報 Yonago Acta medica
en : Yonago Acta medica

巻 43, 号 3, p. 131-140, 発行日 2000-11
出版者
出版者 Tottori University Faculty of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13468049
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00892882
権利
権利情報 Yonago Acta medica 編集委員会
情報源
関連名称 Yonago Acta medica. 2000, 43(3), 131-140
著者版フラグ
出版タイプ VoR
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