{"_buckets": {"deposit": "3d54cc3d-95cc-49a8-82e0-c573ee920e03"}, "_deposit": {"created_by": 1, "id": "5165", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "5165"}, "status": "published"}, "_oai": {"id": "oai:repository.lib.tottori-u.ac.jp:00005165", "sets": ["9", "12", "1090"]}, "author_link": ["19189", "19190", "19188", "19193", "19192", "19191", "2282"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "140", "bibliographicPageStart": "131", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Yonago Acta medica"}, {"bibliographic_title": "Yonago Acta medica", "bibliographic_titleLang": "en"}]}]}, "item_10001_checkbox_27": {"attribute_name": "部局名", "attribute_value_mlt": [{"subitem_checkbox_item": ["i-gakubu"]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In this study, we investigated osteophyte formation processes in guinea pigs with spontaneous osteoarthritis, histochemically and immunohistochemically. Serial thin frontal sections of right knee joints were prepared from Hartley guinea pigs aged 1, 3, 5, 8, 12 and 18 months. The severity of osteoarthritis was evaluated by safranin-O staining, and the animals were classified into 3 groups: mild, moderate and severe. In addition, immunostaining was performed by using primary antibodies against the proliferating cell nuclear antigen (PCNA), type-I, -II and -III collagens, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor. In the mild group, there was fibrous connective tissue continuous with the synovial membrane and covering the margins of the articular cartilage of the medial tibial condyle. This tissue contained spindle-shaped fibroblastic-like cells. These cells were positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the moderate group, the chondrocytes beneath the fibroblastic-like cell layer had proliferated and were clustered together. These chondrocytes were also positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the severe group, this marginal area had been replaced by type-II collagen-positive chondrophytes, which further changed to osteophytes due to the process of endochondral ossification. In guinea pigs, fibroblastic-like cells at the margins of the articular cartilage of the knee joints seemed to be totipotent immature mesenchymal cells. These cells may be the precursors of osteophytes, and IGF-1 appears to be involved in their formation.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Tottori University Faculty of Medicine"}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Yonago Acta medica. 2000, 43(3), 131-140"}]}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Yonago Acta medica　編集委員会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00892882", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13468049", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "EARMAS ID", "attribute_value_mlt": [{"subitem_text_value": "882"}]}, "item_10001_text_29": {"attribute_name": "最新掲載誌名", "attribute_value_mlt": [{"subitem_text_value": "yam;Yonago Acta medica;Yonago Acta medica"}]}, "item_10001_text_32": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Orthopedic Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Department of Orthopedic Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Department of Orthopedic Surgery, Faculty of Medicine, Tottori University"}, {"subitem_text_value": "Department of Orthopedic Surgery, Faculty of Medicine, Tottori University"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ono, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "19188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Yasutsugu"}], "nameIdentifiers": [{"nameIdentifier": "19189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamizaki, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "19190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morio, Yasuo"}, {"creatorName": "Morio, Yasuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2282", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50220041", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50220041"}]}, {"creatorNames": [{"creatorName": "Ono, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Yasutsugu", "creatorNameLang": "en"}], "nameIdentifiers": 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"attribute_value_mlt": [{"subitem_subject": "guinea pig", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin-like growth factor 1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoarthritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteophyte formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "guinea pig", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin-like growth factor 1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoarthritis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteophyte formation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "1", "path": ["9", "12", "1090"], "permalink_uri": "https://repository.lib.tottori-u.ac.jp/records/5165", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-06-22"}, "publish_date": "2018-06-22", "publish_status": "0", "recid": "5165", "relation": {}, "relation_version_is_last": true, "title": ["Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis"], "weko_shared_id": -1}