| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Processes of Osteophyte Formation in Guinea Pigs with Spontaneous Osteoarthritis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
guinea pig |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
insulin-like growth factor 1 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
osteoarthritis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
osteophyte formation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
guinea pig |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
insulin-like growth factor 1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
osteoarthritis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
osteophyte formation |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Ono, Masanori
Yamashita, Yasutsugu
Minamizaki, Takeshi
Morio, Yasuo
Ono, Masanori
Yamashita, Yasutsugu
Minamizaki, Takeshi
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| 著者所属 |
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|
値 |
Department of Orthopedic Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Department of Orthopedic Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Department of Orthopedic Surgery, Faculty of Medicine, Tottori University |
| 著者所属 |
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|
値 |
Department of Orthopedic Surgery, Faculty of Medicine, Tottori University |
| 抄録 |
|
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内容記述タイプ |
Other |
|
内容記述 |
In this study, we investigated osteophyte formation processes in guinea pigs with spontaneous osteoarthritis, histochemically and immunohistochemically. Serial thin frontal sections of right knee joints were prepared from Hartley guinea pigs aged 1, 3, 5, 8, 12 and 18 months. The severity of osteoarthritis was evaluated by safranin-O staining, and the animals were classified into 3 groups: mild, moderate and severe. In addition, immunostaining was performed by using primary antibodies against the proliferating cell nuclear antigen (PCNA), type-I, -II and -III collagens, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor. In the mild group, there was fibrous connective tissue continuous with the synovial membrane and covering the margins of the articular cartilage of the medial tibial condyle. This tissue contained spindle-shaped fibroblastic-like cells. These cells were positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the moderate group, the chondrocytes beneath the fibroblastic-like cell layer had proliferated and were clustered together. These chondrocytes were also positive for PCNA, type-I and -III collagens, IGF-1 and IGF-1 receptor. In the severe group, this marginal area had been replaced by type-II collagen-positive chondrophytes, which further changed to osteophytes due to the process of endochondral ossification. In guinea pigs, fibroblastic-like cells at the margins of the articular cartilage of the knee joints seemed to be totipotent immature mesenchymal cells. These cells may be the precursors of osteophytes, and IGF-1 appears to be involved in their formation. |
| 書誌情報 |
Yonago Acta medica
en : Yonago Acta medica
巻 43,
号 3,
p. 131-140,
発行日 2000-11
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| 出版者 |
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|
出版者 |
Tottori University Faculty of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13468049 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00892882 |
| 権利 |
|
|
権利情報 |
Yonago Acta medica 編集委員会 |
| 情報源 |
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|
関連名称 |
Yonago Acta medica. 2000, 43(3), 131-140 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
43_131-140.pdf (716.5 kB)
