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Alveolar Epithelial Cell Line, A549 Cells Inhibit Neutrophil Apoptosis
https://repository.lib.tottori-u.ac.jp/records/5168
https://repository.lib.tottori-u.ac.jp/records/516861902650-5d0e-4bd9-b61a-a6ee14b53be2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
42_021-029.pdf (89.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Alveolar Epithelial Cell Line, A549 Cells Inhibit Neutrophil Apoptosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 主題 | A549 | |||||
| キーワード | ||||||
| 主題 | laser scanning cytometry | |||||
| キーワード | ||||||
| 主題 | terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | A549 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | laser scanning cytometry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kometani, Yasushi
× Kometani, Yasushi× Tomita, Katsuyuki× Hitsuda, Yutaka× Kometani, Yasushi× Tomita, Katsuyuki× Hitsuda, Yutaka |
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| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Third Department of Internal Medicine, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Though cellular localization at the site of an inflammatory challenge is the critical first step in a neutrophil response, little has been known about the effects of alveolar epithelial cells on the dynamics of neutrophils. To investigate these effects, we used human purified neutrophils incubated with monolayers of human alveolar epithelial cells (A549), quiescent or preactivated with recombinant human tumor necrosis factor (TNF)-α for 24 h. Laser scanning cytometry (LSC) was employed to detect nuclear morphological changes and quantitate DNA strand breaks in neutrophils. The experiments revealed that A549 cells inhibited neutrophil apoptosis, and that this inhibitory effect was enhanced when the A549 cells were preactivated with TNF-α for 24 h. These results suggest that alveolar epithelial cells may be potentially able to contribute to promote inflammatory mechanisms by delaying neutrophil apoptosis. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 42, 号 1, p. 21-29, 発行日 1999-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1999, 42(1), 21-29 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
