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The Relevance of Leukotriene B4 to the Development of Acute Lung Injury Induced by Lipopolysaccharide
https://repository.lib.tottori-u.ac.jp/records/5201
https://repository.lib.tottori-u.ac.jp/records/5201dd841263-30b3-4537-97f0-6e76207d6264
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41_045-052.pdf (37.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | The Relevance of Leukotriene B4 to the Development of Acute Lung Injury Induced by Lipopolysaccharide | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | ALI | |||||
| キーワード | ||||||
| 主題 | LPS | |||||
| キーワード | ||||||
| 主題 | LTB4 | |||||
| キーワード | ||||||
| 主題 | LTB4 receptor antagonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | ALI | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | LPS | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | LTB4 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | LTB4 receptor antagonist | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Hidaka, Kozo
× Hidaka, Kozo× Ishibe, Yuichi× Hidaka, Kozo× Ishibe, Yuichi |
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| 著者所属 | ||||||
| 値 | Department of Anesthesiology and Reanimatology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Anesthesiology and Reanimatology, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acute lung injury (ALI) induced by lipopolysaccharide (LPS) develops by the activation of leukocytes via various mediators. Leukotriene B4 (LTB4) has a strong effect on activation and migration of leukocytes. We investigated the role of LTB4 in the chain leading to the development of ALI induced by LPS, by observing how an LTB4 receptor antagonist, ONO-4057, suppresses or mitigates leukocyte activation and migration. The 36 rabbits used in the experiment were divided into 3 groups: C group (control group of 12 rabbits treated with physiological saline solution only); L group (of 12 rabbits treated with 20 ?g/kg LPS) and L-O group (of 12 rabbits treated with, first, 10 mg/kg ONO-4057, then LPS). Blood samples were taken before, 3 h after and 6 h after the injection of drugs; then the rabbits were exsanguinated. The right and left lungs were removed for wet/dry weight ratio and bronchoalveolar lavage fluid (BALF) measurements, respectively. We measured: the leukocyte counts in the peripheral blood, the chemiluminescence (CL) intensity to measure the amount of oxygen free radical species (active oxygen species) production, the LTB4 concentration in the blood, the complement activity levels (CH50), the polymorphonuclear neutrophil elastase (PMN-E) and myeloperoxidase (MPO) levels in BALF, and the wet/dry weight ratio of the right lung. The leukocyte counts in L and L-O rabbits decreased significantly 3 h after LPS injection, then were regained by the 6th h. Regarding CL (with and without zymosan stimulation), there was no significant difference over time for C group. For L group, the zymosan-stimulated CL showed a significant increase at the 6th h, whereas the non-stimulated CL showed significant increases at the 3rd and 6th h. For L-O group, the zymosan-stimulated CL showed a significant increase at the 6th h, whereas the non-stimulated CL increased after 3 h, then slightly decreased after 6 h. The LTB4 levels showed significant increases at the 6th h for both L and L-O groups. The CH50 showed significant decreases at 6th h for both L and L-O groups. The MPO activity in the BALF was significantly high for both the L and L-O groups. There was a tendency for a high PMN-E level in the BALF for L group. The mean wet/dry weight ratio of the right lung was significantly high for L group, compared to both C and L-O groups. Although an inhibitory effect on LTB4 receptors by ONO-4057 failed to prevent leukocyte migration, it successfully suppressed the activity of non-stimulated CL, MPO and PMN-E, and, as a result, prevented the wet/dry weight ratio from increasing. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 41, 号 1, p. 45-52, 発行日 1998-03 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1998, 41(1), 45-52 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
