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Tuberous Sclerosis 2 Gene Is Expressed at High Levels in Specific Types of Neurons in the Mouse Brain
https://repository.lib.tottori-u.ac.jp/records/5203
https://repository.lib.tottori-u.ac.jp/records/5203c368f84e-49b3-47ab-b6b3-37c794d26609
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41_055-063.pdf (429.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-06-22 | |||||
| タイトル | ||||||
| タイトル | Tuberous Sclerosis 2 Gene Is Expressed at High Levels in Specific Types of Neurons in the Mouse Brain | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | tuberous sclerosis gene | |||||
| キーワード | ||||||
| 主題 | cytoskeletal interaction | |||||
| キーワード | ||||||
| 主題 | neuronal plasticity | |||||
| キーワード | ||||||
| 主題 | in situ hybridization | |||||
| キーワード | ||||||
| 主題 | mouse brain | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | tuberous sclerosis gene | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | cytoskeletal interaction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | neuronal plasticity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | in situ hybridization | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題 | mouse brain | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Saji, Makoto
× Saji, Makoto× Kimura, Mitsuhiro× Maki, Hirotoshi× Nakayama, Kouichi× Nomura, Takanori× Nanba, Eiji× Ohno, Kousaku× Saji, Makoto× Kimura, Mitsuhiro× Maki, Hirotoshi× Nakayama, Kouichi× Nomura, Takanori |
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| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Gene Research Center, Tottori University | |||||
| 著者所属 | ||||||
| 値 | Department of Neurobiology, Faculty of Medicine, Tottori University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by mental retardation, epilepsy and hamartomatous growth in many tissues. The gene (TSC2) encoding a tumor suppressor protein whose mutations cause TSC, has been demonstrated to be expressed at high levels in the adult and developing brain, raising the question of whether or not the TSC2 gene product has unique roles in differentiation related to cytoskeletal interactions within the central nervous system, in addition to a tumor suppressor function. To determine the expression of TSC2 in functionally distinct neuron types of the mouse brain, we carried out in situ hybridization with digoxigenin-labeled riboprobes for the detection of TSC2 mRNA. High levels of the TSC2 gene were in neurons of the pyramidal and dentate granular layer in the hippocampus, cerebellar Purkinje cells, neurons of the piriform cortex, motor neurons in the medulla and interneurons in the striatum, while intermediate levels were in cortical neurons, striatal neurons, septal neurons, thalamic neurons and neurons in the substantia nigra compacta. Thus, the high expression of the TSC2 gene has restricted distribution in specific neuronal types which are characterized by well-developed dendrites and rich in use-dependent long-term changes in synaptic efficacy. These results suggest that the function of the TSC2 gene product may be involved on a cellular basis in neuronal plasticity and relevant to mental retardation observed in TSC patients. | |||||
| 書誌情報 |
Yonago Acta medica en : Yonago Acta medica 巻 41, 号 2, p. 55-63, 発行日 1998-07 |
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| 出版者 | ||||||
| 出版者 | Tottori University Faculty of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13468049 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00892882 | |||||
| 権利 | ||||||
| 権利情報 | Yonago Acta medica 編集委員会 | |||||
| 情報源 | ||||||
| 関連名称 | Yonago Acta medica. 1998, 41(2), 55-63 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
